期刊文献+

分子病理流行病学:精准医疗的基础 被引量:5

原文传递
导出
摘要 十余年来基础医学飞速发展,而相关医学术语被创造和重新定义的速度甚至超越了医学进步的速度。从“循证医学”到“靶向治疗”,至近年来时髦的“个体化医疗”、“转化医学”,直至2015年提出的新的“精准医学”的概念,这一系列新名词的出现代表了基础医学某些领域认识的进步和理念的更迭。如何正确理解其内涵并促进相关学科的发展是亟待思考的重要问题。
作者 来翀 来茂德
出处 《中华病理学杂志》 CAS CSCD 北大核心 2015年第10期689-692,共4页 Chinese Journal of Pathology
  • 相关文献

参考文献23

  • 1Hamburg MA, Collins FS. The path Io personalized medicine[ J]. N Engl J Med, 2010, 363(4) :301-304.
  • 2Chin L, Andersen JN, Futreal PA. Cancer genomivs: from discovely science to pqsmlalized medicine [ J]. Nat Med, 2011,17 ( 3 ) :297-303.
  • 3Mirnezami R, Nicholson J, Darzi A. Preparing for precision medicine[ J]. N Engl J Med, 2012, 366(6) :489-491.
  • 4Katsnelson A. Momentum grows to make ' personalized' medicine more ' precise' [ J]. Nat Med, 2013, 19 (3) :249.
  • 5Collins FS, Varmus H. A new initiative on precision medicine [J]. N Engl J Med, 2015, 372(9) :793-795.
  • 6刘彤华.个性化医学时代的病理学[J].中华病理学杂志,2008,37(4):217-218. 被引量:15
  • 7Longo DL. Tumor heterogeneity and personalized medicine [ J ]. N Engl J Med, 2012, 366(10) :956-957.
  • 8Burrell RA, McGranahan N, Bartek J, et al. The causes and consequences of genetic heterogeneity in cancer evolution [ J ]. Nature, 2013, 501 (7467) :338-345.
  • 9Ogino S, Chan AT, Fuchs CS, et al. Molecular pathological epidemiology of colorectal neoplasia : an emergingtransdisciplinary and interdisciplinary field[ J]. Gut, 2011,60 (3) :397-411.
  • 10Ogino S, Stampfer M. Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology [ J ]. J Natl Cancer Inst, 2010, 102 ( 6 ) :365-367.

二级参考文献41

  • 1刘彤华.表皮生长因子受体家族与靶向性抗癌治疗[J].中华病理学杂志,2006,35(10):577-579. 被引量:21
  • 2张瑰红,施达仁,梁晓曼,侯景辉,康苏娅,朱卫东,李晓兵,邵云,陈丽荣,周燕.显色原位杂交和免疫组织化学检测乳腺癌HER2/neu基因状况和蛋白表达的对照性研究[J].中华病理学杂志,2006,35(10):580-583. 被引量:29
  • 3曾瑄,梁智勇,武莎斐,周炜洵,高洁,刘彤华.乳腺癌HER2蛋白表达阳性者的基因状态分析[J].中华病理学杂志,2006,35(10):584-588. 被引量:40
  • 4Dietel M, Sers C. Personalized medicine and development of targeted therapies : the upcoming challenge for diagnostic molecular pathology. A review. Virchows Arch, 2006, 448 (6) :744-755.
  • 5Watson MA, Perry A, Budhraja V, et al. Gene expression profiling with oligonucleotide microarrays distinguishes World Health Organization grade of oligodendrogliomas. Cancer Res, 2001,61 (5) : 1825-1829.
  • 6Bhattacharjee A, Richards WG, Staunton J, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A, 2001,98(24) :13790-13795.
  • 7Giordano TJ, Shedden KA, Schwartz DR, et al. Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles. Am J Pathol, 2001, 159(4) :1231-1238.
  • 8van't Veer L J, Dai H, van de Vijver MJ, et al. Expression profiling predicts outcome in breast cancer. Breast Cancer Res, 2003,5( 1 ) :57-58.
  • 9Lesko LJ. Personalized medicine: elusive dream or imminent reality? Clin Pharmacol Ther, 2007,81 (6) :807-816.
  • 10Fierz W. Challenge of personalized health care: to what extent is medicine already individualized and what are the future trends? Med Sci Monit, 2004,10(5) :RA111-RA123.

共引文献15

同被引文献22

  • 1Chun Gao,Long Fang,Hong-Chuan Zhao,Jing-Tao Li,Shu-Kun Yao.Potential role of diabetes mellitus in the progression of cirrhosis to hepatocellular carcinoma:a cross-sectional case-control study from Chinese patients with HBV infection[J].Hepatobiliary & Pancreatic Diseases International,2013,12(4):385-393. 被引量:8
  • 2管小琴,赵涌,陈显兵,肖明.从病理学研究生就业现状谈培养模式调整的必要性[J].医学教育探索,2006,5(6):582-582. 被引量:9
  • 3Iacopetta B, Grieu F, Amanuel B. Microsatellite instability in colorectal cancer. Asia Pac J Clin Oncol, 2010, 6(4):260-269.
  • 4Jacob S, Praz F. DNA mismatch repair defects: role in colorectal carcinogenesis. Biochimie, 2002, 84(1):27-47.
  • 5DouiUard J'Y. Microsatellite instability and mismatch repair genes in colorectal cancer: useful tools for managing patients and counseling their relatives. Clin Colorect Cancer, 2010, 9(4): 193-194.
  • 6Lynch PM. Standards of care in diagnosis and testing for hereditary colon cancer. Faro Cancer, 2008, 7(1):65-72.
  • 7Brim H, Mokarram P, Naghihalhossaini F, et al. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer, 2008, 7(1):68-73.
  • 8Cunningham JM, Kim CY, Christensen ER, et al. The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. Am J Hum Genet, 2001, 69(4):780- 790.
  • 9Sargent DJ, Marsoni S, Monges G, et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil based adjuvant therapy in colon cancer. Clin Oncol, 2010, 28(20):3219-3226.
  • 10Guinney J, Dienstmarm R, Wang X, et al. The consensus molecular subtypes of colorectal cancer. Nat Med, 2015, 21(11):1350-1356.

引证文献5

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部