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瞬时受体电位M7在肾脏缺血再灌注损伤中作用的研究进展

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摘要 缺血再灌注损伤包含缺血和再灌注两个过程,缺血性损伤由血流量阻断而使组织缺血缺氧所致,再灌注损伤则是缺血组织恢复血供过程所引起的缺血性组织损伤的进一步加重.肾脏缺血再灌注损伤在肾移植过程中不可避免,并对肾移植的成功率和移植后的肾脏功能恢复有重要影响.肾脏缺血再灌注损伤的机制异常复杂,其中涉及到钙超载导致的线粒体损伤、活性氧自由基（ROS）的作用、能量代谢障碍和多种细胞因子的参与等,因缺血再灌注损伤的发生机制尚未完全明确,预防和治疗肾脏缺血再灌注损伤仍缺乏有效的手段.因此,深入探讨肾脏缺血再灌注损伤的机制,对降低肾脏缺血再灌注损伤的发生率和加强保护性干预有重要意义.
作者 吴静 刘爱芬 杨斌
机构地区 南通大学附属医院肾内科 南通大学医学院基础医学研究室
出处 《中华器官移植杂志》 CAS CSCD 2015年第7期439-442,共4页 Chinese Journal of Organ Transplantation
基金 国家自然科学基金青年科学基金（81300564） 国家自然科学基金面上项目（81170689）
关键词 肾脏缺血再灌注损伤 缺血性损伤 电位 受体 组织缺血缺氧 活性氧自由基 能量代谢障碍 线粒体损伤
分类号 R699.2 [医药卫生—泌尿科学]
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参考文献25

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中华器官移植杂志
2015年 第7期

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