窒息新生儿合并黄疸与血中胃动素及生长抑素水平的关系

Relationship of Jaundice with Plasma Motilin and Somatostatin in Asphyxiated Neonates

目的 :探讨胃动素 (MOT)及生长抑素 (SS)在新生儿窒息合并黄疸中所起的作用及意义。方法 :应用放射免疫法检测 13例窒息合并黄疸新生儿生后 1d、5d血浆MOT及SS的含量 ,并与 2 4例健康足月儿及 18例窒息无黄疸儿对照。结果 :合并黄疸的窒息新生儿血浆SS水平在生后第 1d高于正常对照组及窒息无黄疸儿 (P <0 .0 5或0 .0 1)。至生后第 5dSS水平仍高于正常对照组 (P <0 .0 1)。其余各值间无统计学差异。结论 :窒息新生儿合并黄疸可能是机体的一种自主调节行为 。

Objective: To study the effect of the motilin (MOT) and somatostatin (SS) on the jaundice in asphyxiated neonates. Methods: Plasma MOT and SS were measured by radioimmunoassay in 13 asphyxiated neonates with jaundice and 24 healthy neonates,also in 18 only asphyxiated neonates on the 1st day and the 5th day after birth. Results: The plasma SS level in asphyxiated neonates with jaundice was significantly higher than those in healthy and only asphyxiated neonates on 1st day(P<0.05). The SS level was also higher than that in healthy group on the 5th day (P<0.01). Conclusion: Jaundice occurrence in asphyxiated neonates may be an auto regulation action, and gut hormones be involved in this process.