丙氨酰谷氨酰胺注射液对胃癌患者术后免疫功能的影响

Effect of Alanine Glutamine Injection on Postoperative Immune Function of Gastric Cancer Patients

目的探讨丙氨酰谷氨酰胺注射液对胃癌术后患者免疫功能的影响,同时评价其合理用药方案。方法选取胃癌术后患者64例,随机分为对照组和观察组,各32例。对照组患者术后予以脂肪乳氨基酸(17)葡萄糖(11%)注射液进行肠外营养,观察组患者在对照组基础上加用丙氨酰谷氨酰胺注射液治疗,疗程均为7 d。结果术后2 d,两组患者免疫球蛋白(Ig)及T细胞亚群均较术前明显下降(P<0.05),且两组间未见明显差异(P>0.05);术后7 d,仅对照组T细胞亚群较术前有统计学意义(P<0.05);术后2 d,两组患者前白蛋白及体重指数(BMI)均较术前明显下降(P<0.05),术后7 d观察组患者上述2项指标均达到术前水平,且较对照组同期明显上升(P<0.05)。两组患者不良反应发生率间无明显差异(P>0.05)。结论丙氨酰谷氨酰胺注射液能显著改善胃癌术后患者细胞免疫功能,同时能促进患者创伤修复程度。此外,通过合理的药物配伍,能有效降低药品不良反应,保证用药安全。

Objective To investigate the effect of alanine glutamine injection on the immune function of patients with gastric cancer after gastric cancer surgery, and to evaluate its rational drug use. Methods 64 cases of gastric cancer patients were randomly divided into control group and observation group, 32 cases in each group. After operation, patients in control group were given fat emulsion, amino acids（17） and glucose（11% ） injection for parenteral nutrition, on this basis the observation group used alanyl glutamine injection treatment. The treatment lasted for 7 d. Results 2 d after operation,two groups of patients with Ig and T cell subsets were significantly deereased（P 〈 0.05）,and there was no significant difference between the two groups（P 〉 0.05）. 7 d after operation,only the T cells of the control group were statistically significant（P 〈 0.05）. After 2 d,albumin and BMI of the two groups were decreased significantly compared with the preoperative（P 〈 0. 05）, and 7 d after operation,the two indicators of observation group reached the preoperative level and increased significantly compared with the control group,the difference was statistically significant（P 〈 0. 05）.There was no significant difference in the incidence of adverse reactions between the two groups（ P 〉 0.05）. Conclusion The alanine glutamine injection can improve the cellular immune function in patients with gastric cancer after operation can significantly improve the level of wound healing. In addition, the drug compatibility can effectively reduce the adverse drug reactions and thus ensure the safety of drug use.