氟马西尼与纳洛酮抢救苯二氮类药物急性中毒的疗效比较

Comparison between Flumazenil and Naloxone for Treating Acute Poisoning Caused by Benzodiazepine

目的比较氟马西尼与纳洛酮抢救苯二氮类药物急性中毒的临床疗效。方法选取2012年3月至2015年1月收治的急性苯二氮类药物中毒患者120例,随机分为观察组和对照组,各60例。两组患者均给予常规维生素C解毒、洗胃、导泻,抗生素和速尿利尿治疗,观察组患者加用氟马西尼,对照组患者加用纳洛酮。结果治疗后30 min和1,4,24 h,观察组患者的催醒效果明显优于对照组(P<0.05);两组患者的昏迷程度评分比较,差异有统计学意义(P<0.05);观察组患者的用药剂量明显少于对照组患者,平均意识恢复时间和住院时间均明显短于对照组患者,所用费用明显少于对照组,差异均有统计学意义(P<0.05);观察组总有效率为98.33%,高于对照组的85.00%(P<0.05);两组患者均未出现严重不良反应。结论在抢救苯二氮类药物急性中毒患者时,氟马西尼的催醒效果和催醒速度要优于纳洛酮,且缩短了患者的住院时间,减少了住院费用,值得临床推广。

Objeetive To compare the clinical effect of flumazenil and naloxone in treating acute poisoning of benzodiazepine. Methods Totally 120 patients with acute poisoning caused by benzodiazepine admitted to the hospital from March 2012 to 2015 March were ran- domly divided into the observation group and the control group,60 cases in each group. The two groups were given vitamin C detoxifi- cation, gastric lavage, catharsis, antibiotics and fumsemide diuresis therapy. On this basis, the observation group was given flumazenil, the control group was given naloxone. Results After the treatment of 30 min and 1,4,24 h, the wakening effects of the observation group was significantly higher than that of the control group（P 〈 0.05）;the Glasgow coma score between the two groups had statistical dif- ference（P 〈 0. 05）;the drug dosage in the observation group were significantly less than that of the control group,the average con- sciousness recovery time and hospitalization time were significantly shorter than that of the control group, and the costs was significantly less than that of the control group（ P 〈 0. 05）;the total effective rate of the observation group was 98.33% ;which was significantly higher than 85.00% of the control group（ P 〈 0. 05）. No serious adverse reaction occurred in the two groups. Condusion In the res- cue of benzodiazepine drugs in patients with acute poisoning,the reminder wake effect and push up speed of flumazenil is superior to that of naloxone, and it can reduce hospitalization expense, shorten the hospitalization time, it is worthy of clinical promotin.