不同雾化吸入时机对放射性急性口腔黏膜炎治疗效果的影响

The Influence of Different Periods Aerosol Inhalation Treatment on Acute Oral Mucositis Caused by Radiotherapy

目的了解不同雾化吸入开始时间对放射性急性口腔黏膜炎治疗效果的影响。方法便利抽样法选择2012年10月至2013年7月,上海交通大学附属第六人民医院肿瘤放疗科收治的头颈部恶性肿瘤行根治性放射治疗的患者60例,按入院先后将其分为观察组和对照组各30例,观察组患者放疗开始即给予雾化吸入,对照组患者放疗过程中出现放射性急性口腔黏膜炎后再给予雾化吸入,评价并比较两组患者放射性急性口腔黏膜炎的发生情况、口腔黏膜损伤及疼痛程度。结果放疗期间,观察组患者放射性急性口腔黏膜炎的发生率、口腔黏膜损伤及疼痛程度均低于或轻于对照组患者,差异均有统计学意义(P<0.05或P<0.01)。结论放疗开始即给予雾化吸入,有利于降低头颈部恶性肿瘤行根治性放射治疗患者放射性急性口腔黏膜炎的发生率,减轻黏膜的损伤及疼痛程度,保证放疗的顺利进行,从而提高患者的生活质量。

Objective To observe the influence of different periods aerosal inhalation treatment on acute oral mucositis caused by radiotherapy.Methods Totally 60 patients hospitalized with head and neck cancer and undergoing radiotherapy were randomly divided into observation group and control group,with 30 cases in each group.The observation group received aerosol inhalation while the radiotherapy started,while the control group only received aerosol inhalation while the acute oral mucositis appeared.The incidence rate of acute oral mucositis caused by radiotherapy,injury of oral mucosa and pain degree were compared between two groups.Results During the radiotherapy,the incidence rate of acute oral mucositis caused by radiotherapy,injury of oral mucosa and pain degree in observation group were less or lower than which in control group（P〈0.05 or P〈0.01）.Conclusion Giving inhalation treatment at the beginning of radiotherapy can reduce the incidence rate of acute oral mucositis caused by radiotherapy and the injury level of oral mucosa,and also ease the pain,which guarantees the success of radiotherapy,and thus to improve patient＇s quality of life.