高脂血症性急性胰腺炎患者D-二聚体和凝血指标的变化及其与血钙的关系被引量：4

Changes of D-dimer, Coagulation Indices and Relation with Calcium in Patients with Hyperlipidemic Acute Pancreatitis

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摘要目的研究高脂血症性急性胰腺炎患者D-二聚体和凝血指标的变化与血钙的关系。方法选择2013年1月至2014年12月高脂血症性急性胰腺炎患者64例。根据疾病严重程度分为轻度胰腺炎组和中度胰腺炎组。检测凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原、凝血酶时间和D-二聚体,并同时检测血钙。比较两组上述指标的不同及其和血钙的关系。结果轻度胰腺炎组的凝血酶原时间、纤维蛋白原、D-二聚体均明显低于中度胰腺炎组而血钙则相反。凝血酶原时间、纤维蛋白原、D-二聚体与血钙均为负相关(r分别为-0.338、-0.254和-0.248,P分别为0.006、0.042和0.048)。结论高脂血症性急性胰腺炎患者的凝血酶原时间、纤维蛋白原、D-二聚体均随病情加重而升高。而血钙下降可能与凝血酶原时间、纤维蛋白原、D-二聚体相关。 Objective To profile the changes of D-dimer, coagulation indices and relation with calcium（Ca） in patients with hyperlipidemic acute pancreatitis（HLAP）. Methods From Jan 2013 to Dec 2014, 64 HLAP patients were admitted to our hospital. Patients were divided into mild acute pancreatitis（MAP） group and moderately severe acute pancreatitis（MSAP）group according to the disease severity.Prothrombin time（PT）,activated partial thromboplastin time, fibrinogen（Fib）, thrombin time and D-dime were measured. Also, Ca were measured.Compare the difference between 2 groups and relation with Ca. Results Level of PT, Fib and D-dimer were significantly increased in MSAP group than MAP group. On the contrary, Ca was significantly decreased. PT, Fib,D-dimer were negative correlation with Ca（r=-0.338,-0.254 and-0.248, P=0.006, 0.042 and 0.048,respectively）. Conclusions PT, Fib and D-dimer are increased with severity of HLAP. Decreased Ca may have correlation with increased PT, Fib and D-dimer in HLAP patients.

作者张冬磊郝建宇杨宁

机构地区北京首都医科大学附属北京朝阳医院消化内科北京首都医科大学附属北京朝阳医院内分泌科

出处《中国病案》 2015年第10期91-93,共3页 Chinese Medical Record

关键词高脂血症性急性胰腺炎 D-二聚体纤维蛋白原血钙 Hyperlipidemic acute pancreatitis D-dimer Fibrinogen Calcium

分类号 R576 [医药卫生—消化系统]

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