药物致急性肾损伤22例临床分析

Clinical analysis of 22 cases of acute renal injury caused by drugs

目的:探讨药物致急性肾损伤的临床病理特点,为合理用药提供参考.方法:分析2013-12/2015-02我院收治的22例药物致AKI患者的病因、临床病理特点及治疗方法.结果:涉及AKI的药物主要有脱水剂7例(31.82%);抗生素类15例(68.18%),其中甘露醇居首位,且未见不同分级患者之间的转归差异(P>0.05).结论:甘露醇和部分抗生素可导致急性肾损伤,在临床用药过程中应加强监测和合理用药.在AKI发生后应立即停药,给予及时有效治疗.

AIM: To investigate the clinical and pathological characteristics of acute renal injury caused by drugs, and provide references for drug?use. METHODS: A total of 22 patients with acute renal injury caused by drugs in our hospital from December 2015 to February 2013 were selected, and the etiology, clinical and pathological characteristics and treatment were analyzed retrospectively. RESULTS: The drugs involved in acute kidney injury concluded dehydrating agent in 7 cases (31.82%), antibiotics in 15 cases ( 68. 18%) , and mannitol ranks first. There was no outcome differences between patients with different grades ( P>0.05). CONCLUSION:Mannitol and some antibiotics can cause acute kidney injury, so we should strengthen monitoring and rational drug?use in the clinical course of medication. If acute kidney injury occures, we should stop drug instantly and give timely and effective treatment.