清热解毒中药降糖作用及机制研究进展

Research progress in hypoglycemic effect and mechanism of heat-clearing and detoxifying Chinese materia medica

中医认为热毒蕴结是糖尿病发生发展的重要病理机制之一,在辨证论治的基础上,使用清热解毒法能有效治疗糖尿病。清热解毒中药能通过保护胰岛细胞,改善胰岛素抵抗,调节糖脂代谢、调节胰高血糖素样肽-1(GLP-1)、炎症因子和肠道菌群等降低血糖。将对清热解毒方药降糖作用及其机制进行探讨。

Heat-toxin stagnation is regarded to be an important pathologic mechanism of diabetes mellitus（DM） in terms of traditional Chinese medicine. Treating DM with heat-clearing and detoxifying principle on the basis of syndrome differentiation proves to be effective. Heat-clearing and detoxifying Chinese materia medica can decrease blood sugar by protecting islet β-cell, improving insulin resistance, regulating glucose metabolism and lipid metabolism, regulating GLP-1, inflammatory cytokines, and intestinal microflora.