300例病毒性肝炎患者的fibroscan结果分析

Fibroscan results analysis of 300 patients with viral hepatitis

目的进一探讨Fibroscan检查在慢性病毒性肝炎患者中的诊断价值。方法对300例病毒性肝炎病人进行Fibroscan检查并与100例正常人进行对照。结果 CHB肝功正常组的肝纤维化检出率35%,与过去肝穿检出率一致。CHB肝功不正常的肝纤维化检出率100%,丙肝肝纤维化检出率58%,肝硬化检出率83.3%。LSM在肝功正常到肝硬化之间逐渐升高,与肝脏的纤维化程度呈正相关。组间差异有统计学意义(P=0.000<0.001)。结论肝脏瞬时弹性检测,对肝纤维化有很好的评估价值。对肝功正常的乙肝患者,可以提供抗病毒治疗指征。减少肝穿。

Objective To investigate the clinical value of Fibroscan for detecting liver fibrosis in patients with chronic hepatitis. Methods 300 patients were enrolled in this study and underwent liver stiffness measurement（LSM） by Fibroscan before liver biopsy. The levels of serum ALT and AST were detected via standard biochemical assays. Results The extent of LSM increased with increased extent of liver fibrosis, and the changes the groups（all P〈0.001）. LSM was significantly positively related to the stage of liver fibrosis. has very good clinical value for diagnosing liver fibrosis in patients with chronic hepatitis.