贲门腺癌行全胃切除术与近侧胃大部切除术的疗效对比

Comparative efficacy of total gastrectomy and proximal gastrectomy in treatment of GCA

目的对比分析全胃切除术与近侧胃大部切除术治疗贲门腺癌的临床疗效。方法回顾性分析2008年8月—2010年2月间在本院治疗的106例贲门腺癌患者的临床记录资料,将其随机分为两组。治疗组53例,行全胃切除术;对照组53例,行近侧胃大部切除术。治疗后比较两组疗效。结果治疗后,治疗组的总有效率为90.57%,高于对照组的75.47%,差异有统计学意义(P<0.05)。治疗组的3年生存率、5年生存率均高于对照组均有统计学意义(均P<0.05)。治疗组的清蛋白、总蛋白、血红蛋白水平虽略高于对照组,差异均无统计学意义(均P>0.05)。治疗组的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论全胃切除术治疗贲门腺癌的临床疗效显著,值得临床推广应用。

Objective To investigate clinical efficacy of total gastrectomy and proximal gastrectomy in treatment of gastric cardiac adenocarcinoma. Methods 106 patients with gastric cardiac adenocarcinoma in our hospital from August 2008 to February 2010 were divided into the treatment group（53） , treated by total gastrectomy, and the control group （53） , treated by proximal gastrectomy. The clinical efficacy of two groups were analyzed. Results After treatment,the total effective rate of the treatment group （90.57%） was significantly higher than that of the control group （75.47%） （P 〈 0.05 ）. The 3 - year survival rate and 5 - year survival rate of treatment group were higher than that of the control group （ P 〈 0.05 ）. Albu- min , total protein, hemoglobin level of treatment group were higher than the control group （ P 〉 0.05 ）. The incidence of adverse events in the treatment group was signif scantly lower than the control group（ P 〈 0.05 ）. Conclusions The total gastrectomy in treatment of gastric cardiac adenocarcinoma has significant efficacy.