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地佐辛注射液依赖一例 被引量:10

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摘要 患者男,35岁,医师,因“情绪低落、悲观绝望、无兴趣感伴反复应用地佐辛注射液2年”于2014年9月5日入住我院.患者2012年初无诱因出现情绪低落、悲观绝望,感觉活着没意思,睡眠差,当地精神科就诊,考虑抑郁症,予帕罗西汀等抗抑郁治疗,疗效差.之后患者因睡眠差自行肌肉注射地佐辛注射液(dezocine injection)5 mg/次,用药几分钟后感觉抑郁情绪有所缓解,浑身放松,昏昏欲睡,但持续时间短暂,几小时后抑郁情绪恢复至用药前状态,此后患者反复注射地佐辛注射液近2年,用药间隔逐渐缩短(从初期的每月2~3次,增加至就诊时的5~6次/d),用药剂量逐渐增加(从初期的5 mg/次,增加至就诊时的20 mg/次).
出处 《中华精神科杂志》 CAS CSCD 北大核心 2015年第5期319-320,共2页 Chinese Journal of Psychiatry
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  • 1Liu R, Huang XP, Yeliseev A, et al. Novel molecular targets of dezocine and their clinical implications[J].Anesthesiology, 2014, 120(3):714-723.doi: 10.1097/ALN.0000000000000076.
  • 2Zhang H, Shi YG, Woods JH, et al. Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binahorphimine: behavioral and BDNF mRNA expression studies[J].Eur J Pharmacol, 2007, 570(1-3):89-96. doi: 10.1016/j.ejphar.2007.05.045.
  • 3Carr GV, Bangasser DA, Bethea T, et al. Antidepressant-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats[J].Neuropsychopharmacology, 2010, 35(3):752-763.doi: 10.1038/npp.2009.183.
  • 4Chartoff E, Sawyer A, Rachlin A, et ah Blockade of kappa opioid receptors attenuates the development ofdepressive-like behaviors induced by cocaine withdrawal in rats[J].Neuropharmacology, 2012, 62(1):167-176.doi:10.1016/ j.neuropharm.2011.06.014.
  • 5Gilhnan KW, Parker MF, Silva M, et al. Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dural NK1 antagonism and SERT inhibition for the treatment of depression[J].Bioorg Med Chem Lett, 2013, 23(2):407-411.
  • 6Joensuu M, Tolmunen T, Saarinen PI, et al. Reduced midbrain serotonin transporter availability in drug-naive patients with depression nmasured by SERT-specific [(123)I]nor-beta-CIT SPECT imaging[J].Psychiatry Res, 2007, 154(2): 125-131 .doi: 10.1016/j .pseyehresns.2006.08.O01.
  • 7Wang C, Li L, Shen B, et al. A multieenter randomized double-blind prospective study of the postoperative patient controlled intravenous analgesia effects of dezocine in elderly patients[J].Int J Clin Exp Med, 2014, 7(3):530-539.

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