十六烷基三甲基溴化铵/壳聚糖-碳纳米管修饰玻碳电极的制备与应用

Determination of Acetaminophen by Cetyltrimethyl Ammonium Bromide/Chitosan-Carbon Nanotubes Modified Glassy Carbon Electrode

制备了十六烷基三甲基溴化铵/壳聚糖-碳纳米管修饰玻碳电极,并建立了一种新的测定对乙酰氨基酚（PCT）的电化学分析方法。用循环伏安法研究了该修饰电极的选择性和灵敏度,以及PCT在修饰电极上的氧化还原特性。结果表明该修饰电极对PCT具有显著的催化氧化和选择作用。在pH=5.6的磷酸盐缓冲溶液中,PCT浓度在0.05~2mg/mL范围内与其氧化峰电流呈良好的线性关系,相关系数R2=0.9858,检出限为0.01mg/mL。该方法操作简便,可用于药物片剂中PCT含量的测定。

The cetyltrimethyl ammonium bromide/chitosan-carbon nanotubes modified glassy carbon electrode was prepared for determination of acetaminophen.The modified electrode was studied by cyclic voltammetry and the results showed that the modified electrodes had significant catalytic oxidation and selectivity for acetaminophen.In phosphate buffer solution（pH=5.6）,the oxidation peak current had a good linear relationship over the concentration of acetaminophen in 0.05-2 mg/mL with the detection limit of 0.01 mg/mL.The method is simple and can be used for the determination of content of acetaminophen tablets.