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半乳凝集素-1在母-胎免疫耐受机制的研究进展

Research process of galectin-1's effect on the fetal-maternal immunotolerance
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摘要 正常妊娠的维持有赖于多种因素的参与,如母-胎免疫耐受、足量的激素支持等,近年来的研究显示,半乳凝集素-1可以介导母-胎免疫耐受,并通过与黄体酮的协同作用参与正常妊娠的维持。而且,半乳凝集素-1与反复自发性流产(RSA)、子痫前期和妊娠期糖尿病的发生均有关联。对半乳凝集素-1的研究可以帮助我们更加深入地了解正常妊娠与异常妊娠,从而为妊娠相关疾病的诊断及治疗提供新的研究思路。 Normal pregnancy is attributed to many factors, such as fetal-maternal immunotolerance,abundant hormones and etc. Recent researches find that galectin-1 can regulate fetal-maternal immunotolerance,and cooperate with progesterone to play an important role in maintaining normal gestation. Galectin-1 takes part in the occurence of recurrent spontaneous abortion（RSA）, preeclampsia and gestational diabetes mellitus. Studies about galectin-1 help us to further understand the process of normal and abnormal pregnancy, and provide fresh ideas for the diagnosis and treatment of diseases associated with pregnancy.
作者 牛甜甜 王海燕
机构地区 复旦大学附属妇产科医院
出处 《生殖与避孕》 CAS CSCD 北大核心 2015年第10期719-723,共5页 Reproduction and Contraception
基金 国家自然科学基金项目 项目号:81373868
关键词 半乳凝集素-1 T细胞分化 母-胎免疫耐受 黄体酮 反复自发性流产(RSA) galectin-1 T cell differentiation fetal-maternal immunotolerance progesterone recurrent spontaneous abortion（RSA）
分类号 R714.2 [医药卫生—妇产科学]
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参考文献37

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二级参考文献63

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生殖与避孕
2015年 第10期

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