β-胡萝卜素/介孔纳米材料新型载药体系的制备与稳定性研究

Preparation and stability of β-carotene loaded using mesoporous silica nanoparticles as carriers system

以1,3,5-三甲基苯(1,3,5-TMB)作为扩孔剂,对介孔纳米材料MCM-41(mobil company of matter)进行了扩孔改性,采用有机溶剂浸渍法将非水溶性的β-胡萝卜素载入到扩孔后的MCM-41的介孔孔道中,得到了β-胡萝卜素/MCM-41新型载药体系。分别利用TEM,FT-IR,元素分析和低温N2吸附-解吸附对MCM-41以及载药体系进行了表征;研究了载药体系中β-胡萝卜素的最佳载药时间,载药量以及体外稳定性等。通过表征,发现采用水热合成法制备的MCM-41具有良好的球形度,规则的孔径结构;扩孔改性后的MCM-41作为药物载体具有较短的载药时间且药物的载药量有明显提高,并且组装体中β-胡萝卜素的稳定性得到了一定程度的改善。该新型载药体系的研究为β-胡萝卜素的广泛应用提供了新的思路。

1,3,5-Trimethylbenzene（ 1,3,5-TMB） was used as the pore-enlarging modifier to expand the pore size of MCM-41（ mobil company of matter） mesoporous silica nanoparticles. The solvent impregnation method was adopted to assemble non-water-soluble β-carotene into the pore channel of MCM-41. The MCM-41 and drug assemblies were characterized by TEM,FT-IR,elemental analysis and N2adsorption-desorption. The results showed that MCM-41 has good sphericity and regular pore structure. The research also investigated the optimal loading time,the drug loading and the vitro stability of the β-carotene. As a drug carrier,the modified MCM-41 showing a shorter drug loading time,the drug loading as high as 85. 58% and the stability of β-carotene in drug assemblies has improved. The study of this new formulation provides a new way for β-carotene application.