过氧化物酶体增殖物激活受体γ辅激活因子1α与肌纤维类型转化及其表达调控研究进展

Research Progress on the Relationship between Peroxisome Proliferators-activated Receptor-γ Coactivator-1α and Muscle Fiber-type Switching,and its Expression Regulation

过氧化物酶体增殖物激活受体γ(PPAR-γ)辅激活因子1α(PGC-1α)是一种多功能的转录调节因子,广泛参与线粒体生物合成、能量代谢和糖脂代谢等过程。PGC-1α可通过多条信号通路调控畜禽骨骼肌肌纤维类型的转化,从而影响肉品质。因此,在转录和翻译水平上对PGC-1α的表达调控进行深入研究将为今后改善肉品质提供新的思路。日粮营养作为一种调控畜禽肉品质的重要方式,近年来,关于营养对PGC-1α活性的影响研究也逐渐开展起来,并取得了一些进展。作者概述了PGC-1α的结构、组织表达特点及PGC-1α调控肌纤维类型转化的机制,重点在转录和翻译水平介绍了PGC-1α的表达调控机制,并综述了日粮营养对PGC-1α活性的影响。

Peroxisome proliferators-activated receptor-γ（PPAR-γ）coactivator-1α（PGC-1α）is a versatile transcriptional regulator.PGC-1αis characteristically involved in the regulation of several crucial cellular pathways including mitochondrial biogenesis,fatty acid oxidation,gluconeogenesis and so on.PGC-1αis significantly associated with meat quality,since it may affect the fibertype switching through several signaling pathways in livestock and poultry.Therefore,study on PGC-1αexpression regulation in the transcription and post-translation level can provide new strategies for improving the meat quality.In recent years,the effect of dietary nutrition on PGC-1αhas been also researched gradually for its importance in the regulation on meat quality in livestock and poultry.This review described the structure and expression patterns in tissues of PGC-1α,and its regulatory mechanism on muscle fiber-type switching,focusing on recent advances on its expression regulation in the transcription and post-translation level,also summarized the effect of dietary nutrition on PGC-1α.