microRNAs作为结核分枝杆菌感染标志物的研究进展

Progress in MicroRNAs as Infective Biomarkers of Infection of Mycobacterium tuberculosis

微小RNA(microRN.As)是一类长度约为22个核苷酸的非编码单链RNA分子,它参与基因转录后的表达调控,在免疫系统的调控和运行中具有重要作用。结核分枝杆菌是典型的胞内寄生菌,其感染能够引起人畜共患结核病。从microRNAs与结核免疫机制的相关性以及在结核分枝杆菌感染过程中巨噬细胞、外周血单核细胞及血清中microRNAs表达谱变化等方面,进行综述microRNAs作为结核分枝杆菌感染标志物的研究现状,以期为动物结核病检测提供理论参考。

MicroRNA is a kind of non - coding single stranded RNA molecules formed by about 22 nucleotides. It involved in regulation after gene transcription and plays an important role in the regulation and operation of the immune system. Mycobacterium tuberculosis is the typical parasitic bacterium in the cell, and its infection can cause zoonosis. It is reviewed in this article that the progress in microRNAs as infective biomarkers of infection of Mycobacterium tuberculosis from the correlation of microRNAs with tuberculosis immune mechanism and microRNAs expression changes in macrophages, mononuclear cells and serum in the process of infection of Mycobacterium tuberculosis, which may provide the theoretical reference for the detection of animal tuberculosis.