普乐可复治疗儿童难治性肾病综合征的疗效及其对患儿血清相关炎性因子的影响研究

Efficacy of Tacrolimus capsules in the treatment of children with refractory nephrotic syndrome and its effect on related serum inflammatory factors

目的 研究普乐可复治疗难治性肾病综合征的疗效及其对患儿血清相关炎性因子的影响.方法 将我院收治的难治性肾病综合征75例随机分为两组,两组均给予激素治疗,实验组38例在激素治疗基础上给予普乐可复治疗,对照组37例在激素治疗基础上给予环磷酰胺治疗,对比两组的临床疗效及对患儿血清相关炎性因子的影响.结果 实验组、对照组总有效率分别为94.71％、72.97％,实验组治疗后血清IL-2[（190.15±14.18） pg＆#183;ml-1]、sIL-2R[（183.14±17.84）U/ml]、甘油三脂[（1.98±0.64）U/L]、血浆白蛋白[（44.87±6.85） g/L]、24h尿蛋白[（0.75±0.14）mg]改善较对照组治疗后明显,两组比较差异有统计学意义（P＜0.05）.结论 普乐可复治疗难治性肾病综合征,疗效显著,血清IL-2、sIL-2R、甘油三脂、血浆白蛋白、24 h尿蛋白改善明显,效果较为理想.

Objective To study the efficacy of Tacrolimus capsules in the treatment of children with refractory nephrotic syndrome and its effect on related serum inflammatory factors.Methods 75 cases of refractory nephrotic syndrome in our hospital were randomly divided into two groups.Two groups were treated with hormone therapy, 38 cases in experimental group received Tacrolimus capsules, 37 cases in control group received cyclophosphamide.Compared the clinical efficacy of two groups and related serum inflammatory factors.Results The total effective rate in experimental group and control group were 94.71%, 72.97% respectively.After treatment, serum IL-2 [（190.15±14.18）pg/ml], sIL-2R [（183.14±17.84） U/ml], triglycerides [（1.98±0.64）U/L], serum albumin [（44.87±6.85）g/L], 24 h urine protein [（0.75±0.14） mg] in experimental group improved more significantly that those in control group （P〈0.05）.Conclusion Tacrolimus capsules in the treatment of children with refractory nephrotic syndrome has a significant effect, with serum IL-2, sIL-2R, triglycerides, serum albumin, 24 h urine protein improving significantly.