睾丸酮丛毛单胞菌临床分布及耐药性分析

Clinical Distribution and Drug Resistance of Comamonas Testosteroni

目的了解睾丸酮丛毛单胞菌在临床标本中的分布及耐药性，为临床治疗提供依据。方法对本院2013年7月～2014年12月临床分离的睾丸酮丛毛单胞菌引起的感染分布及药敏结果进行回顾性分析。结果2年各种标本中共分离培养出睾丸酮丛毛单胞菌23株，标本全部来源于阑尾脓液和腹腔分泌物，分别占91．3％和8．7％；感染发生在普外科病区和ICU病区，分别占95．7％和4．3％；睾丸酮丛毛单胞菌对环丙沙星耐药率最高，为21．7％，对替卡西林、替卡西林／克拉维酸、哌拉西林／他唑巴坦、头孢吡肟、亚胺培南、美洛培南、头孢他啶、阿米卡星、庆大霉素、妥布霉素、哌拉西林、复方新诺明的敏感率高达100．0％。结论本院检出的睾丸酮丛毛单胞菌对各种抗菌药物均比较敏感，应规范抗菌药物的临床应用，减少耐药性菌株产生及扩散。

Objective To understand distribution of Comamonas testosteroni in the clinical specimens and analyze the drug resistance so as to guide the clinical treatment. Methods From July 2013 to December 2014,the distribution of clinical isolates of C. testosteroni and the result of drug susceptibility testing were retrospectively analyzed. Results A to- tal of 23 strains of C. testosteroni were isolated from various specimens during the 2 years, 91.3% of which were isolated from the appendix pus, and 8. 7% from abdominal secretions. Patients with infections in general surgery accounted for 95.7%,and the patients with infections in the ICUs accounted for 4. 3%. The drug resistance rate of C. testosteroni to ciprofloxacin was highest （21.7%）. 100 % of the isolates were found to be sensitive to ticarcillin, ticarcillin/clavulanic acid, piperacillin/tazobactam, cefepime, imipenem, meropenem, ceftazidime, amikacin, gentamicin, tobramycin, piperacillin, paediatrie compound, and sulfamethoxazole. Conclusion C. testosteroni strains are sensitive to various antibiotics,so the clinical use of antibiotics should be standardized to prevent from the emergence and spread of the drug resistant strains.