GBE对运动大鼠中脑SOD活力、MDA含量和DA浓度的影响

Effects of GBE Motion Midbrain SOD Activity,MDA Concentration and DA Concentrations

观察补充GBE对递增负荷运动大鼠中脑内SOD活力、MDA含量和DA浓度的影响并进行研究分析。将32只雄性SD大鼠随机分为Control组、E组、GBE组、GBE+E组4组,每组8只。GBE和GBE+E组给药2w,而E和GBE+E组运动2w,末次运动24h后断头处死,测试中脑SOD活力、MDA含量和DA浓度。末次运动24h后断头处死,测试中脑SOD活力、MDA含量和DA浓度。结果显示:与Control组相比,GBE组大鼠中脑MDA的含量显著下降、SOD的活力和DA浓度显著上升;E组大鼠中脑MDA的含量显著上升、DA的浓度显著下降。与E组相比,GBE+E组大鼠中脑MDA的含量显著下降、DA浓度上升。结果表明:GBE抑制中脑内运动性氧化应激水平上升可能是GBE延缓运动性疲劳,延长运动时间的机制之一。

Objective： Exogenous administration of GBE on concentration of SOD、MDA and DA in brain of rats that experienced incremental exercises. Methods： 32 male SD rats were randomly divided into 4 groups,Control group,E group,GBE group,GBE ＋ E group,each group of eight. GBE and GBE ＋ E groups would be fed GBE for2 weeks,while E and GBE ＋ E groups would exercise for two weeks,24 hours after the last movement decapitated,testing concentration of SOD,MDA and DA in brain. Results： Compared to Control group,MDA content in brain of GBE group decreased dramatically,while concentration of SOD and DA increased; MDA content of E group increased significantly while concentrations of DA declining. Compared to E group,MDA content in brain of GBE ＋ E group decreased dramatically,while DA increased. Conclusion： GBE can restrain the increasing of exercise-induced oxidative stress in midbrain and that may be one of the mechanisms to delay the sports fatigue.