PWI在肝硬化增生性结节诊断中的应用

Application of PWI in diagnosing the cirrhotic dysplastic nodules

目的 :探讨PWI在肝硬化增生性结节(dysplastic nodule,DN)诊断中的应用。方法 :回顾性分析经病理证实的40例DN患者的PWI资料,获得每个DN的时间-信号强度曲线(time intensity curve,TIC)和峰值时间(time to peak,TTP),计算肝脏动脉灌注指数(hepatic perfusion index,HPI)。结果:28例28个DN为低级别DN(low grade DN,LGDN),TIC主要呈缓升缓降型20个,TTP为(41.56±1.67)s,HPI为0.27±0.04;12例14个DN为高级别DN(high grade DN,HGDN),TIC主要呈速升缓降型11个,TTP为(39.81±2.36)s,HPI为0.45±0.06。结论:PWI能客观地反映DN的血流情况,有助于DN的诊断和鉴别诊断。

Objective：To investigate the application of MRI perfusion weighted imaging in diagnosing cirrhotic dysplastic nodules （DN）. Methods：MRI perfusion weighted imaging of 40 patients with 42 DN proved by pathology were reviewed and ana- lyzed. Time-intensity curve （TIC） of each DN was got. The time to peak （TrP） was recorded and hepatic perfusion index （HPI） was calculated. Results：28 DN of 28 patients were low grade dysplastic nodules （LGDN）,their TIC mainly rose slowly and decreased slowly （20/28,71%）. Their TI？P and HPI were 41.56 ± 1.67s and 0.27 ±0.04,respectively. 14 DN of 12 patients were high grade dysplastic nodules （HGDN）,their TIC mainly rose quickly and decreased slowly（11/14,79%）,TYP and HPI were 39.81± 2.36s and 0.45±0.07,respectively. Conclusions：MRI perfusion weighted imaging could objectively reflect the blood supply information of the DN,and it is helpful in diagnosis and differential diagnosis of DN.