中老年男性和绝经后女性脑梗死患者血清性激素变化的临床观察

Clinical observation of changes of serum sex hormones in elderly men and postmenopausal women patients with cerebral infarction

目的探讨中老年男性和绝经后女性脑梗死患者血清性激素变化。方法选取中老年男性和绝经后女性脑梗死患者为观察组(n=125),同期健康体检者为对照组(n=140)。观察组中中老年男性患者65例,其中轻型40例,中-重型25例,绝经期后女性患者60例,其中轻型35例,中-重型25例;对照组中中老年男性80例,绝经期后女性60例。采用放免法测定各组激素水平,分析中老年男性和绝经后女性脑梗死患者中激素水平的变化。结果中老年男性患者雌二醇(E2)水平和E2/T比值高于男性对照组(P<0.01),绝经后女性患者E2水平低于女性对照组(P<0.01)。男性和绝经后女性中-重型患者E2和T水平均高于轻型患者,差异有统计学意义(P<0.05)。结论中老年男性E2水平和E2/T比值升高、绝经后女性E2水平降低,可能与脑梗死的发病有关;性激素水平与脑梗死病情程度密切相关,中-重型E2和T水平较轻型明显增高。

Objective To investigate the changes of serum sex hormones in elderly men and postmenopausal women patients with cerebral infarction. Methods Cerebral infarction patients were selected for the study. Healthy persons were selected as control group. Hormones levels were measured by radioimmunoassay. Results E2 level and E2/ T ratio in elderly male patients were higher than those of control group（P 〈0.01）; E2 level in postmenopausal female patients was lower than that of control group（P〈0.01）. The E2 and T levels in male and postmenopausal women of moderate or severe patients were higher than that in mild patients; the difference was statistically significant. Conclusions The E2 level and E2/ T ratio in elderly male were elevated; the E2 level in postmenopausal female was decreased, which might be one of risk factors of cerebral infarction. The sex hormone levels were related with the severity of cerebral infarction; the E2 and T levels in moderate or severe patients were higher than that in mild patients.