异基因造血干细胞移植后生存质量评价方法及影响因素

Assessment methods and influencing factors for quality of life after allogeneic hematopoietic stem cell transplantation

异基因造血干细胞移植是许多血液肿瘤有效乃至唯一的根治方式。随着移植技术的进步,生存质量(QOL)成为评价移植疗效的重要指标。一些因素被认为与移植后QOL的恢复相关,其中年龄、性别、移植后存活时间以及移植物抗宿主病被认为是影响患者QOL恢复的最重要原因。通过对患者移植后QOL的深入评估,可以找出移植后不良的QOL影响因素,并期望通过对其进行积极干预,最终改善患者QOL,让其能够真正回归正常的生活,这将是造血干细胞移植的最终目标。

Allogeneic hematopoietic stem cell transplantation（ allo-HSCT） is an effective option and sometimes the only treatment for hematological malignancies. With the development of the allo-HSCT technique,increasing numbers of patients with hematological disease have achieved longterm survival. Quality of life（ QOL） should be considered as an important index for evaluating the efficacy of allo-HSCT. Some factors may be associated with QOL after allo-HSCT,such as age,gender,survival after allo-HSCT,and graft-versus-host disease. Evaluation of QOL and finding out the factors which influencing the QOL may help to further improve the QOL of allo-HSCT recipients,and help them return to normal life.