三维适形放疗联合腹腔神经丛阻滞治疗局部晚期胰腺癌疼痛

Three Dimensional Conformal Radiotherapy combined with Solar Plexus Block in Treatment of Locally Advanced Pancreatic Cancer Pain

目的:探讨三维适形放疗联合B超引导下无水酒精腹腔神经丛阻滞术治疗局部晚期胰腺癌的疼痛效果,判断其安全性和可行性及患者生活质量改善情况。方法:应用单因素分析方法,回顾性分析63例局部晚期胰腺癌患者的临床资料,63例局部晚期胰腺癌患者根据随机数字表分成对照组(31例)和联合治疗组(32例),联合治疗组先行B超引导下腹腔神经丛阻滞术,术后第2 d进行三维适形放疗,对照组则仅采用三维适形放疗;比较两组治疗前后的疼痛缓解情况及Karnofsky评分情况,分析其安全性和可行性。结果:对照组和联合治疗组疼痛缓解率为48.3%和84.3%,对照组卡氏评分没有发生显著变化,联合治疗组卡氏评分提高率56.3%;两组间副反应差异不明显。结论:三维适形放疗联合腹腔神经丛阻滞术治疗局部晚期胰腺癌效果较单用三维适形放疗优越,能够缓解疼痛,提高患者生活质量。

ObjectiveTo explore the efficacy of three dimensional conformal radiotherapy combined withsolar plexus block in the treatment of locally advanced pancreatic cancer pain,and to observe the safety,feasibil-ity and the patients′quality of life.MethodsSixty-three locally advanced pancreatic cancer patients wererandomly divided into two groups：the control group（31cases） and the combination group（32cases）.In the combi-nation group,ultrasound guided celiac plexus block was first performed.Then three-dimensional conformal radio-therapy was did 2 days later.In the control group,patients were treated with three dimensional conformal radia-tion therapy alone.The pain relief and KPS score were compared between the two groups before and after treat-ment.The security and feasibility of treatment were analyzed.ResultsThe pain relief rates of the controlgroup and combination group were 48.3% and 84.3% respectively.The increasing rate of KPS score in controlgroup was not significant,but in the combination group,it was 56.3%.ConclusionThree dimensional confor-mal radiotherapy combined with solar plexus block technique is better in the treatment of locally advanced pan-creatic cancer patients.It can relieve pain and improve intervention the patient＇s quality of life.