规律性有氧运动对成年人血浆白介素-6水平影响的Meta分析

A Meta-analysis of Regular Aerobatic Exercise on Plasma IL-6 Level in Adults

目的:评价规律性有氧运动对成年人血浆中IL-6浓度的影响效果。方法:电子检索PubMed、Embase、Web of Science、万方、维普和知网数据库,检索期限均从各个数据库收录起始年限起至2014年12月,全面收集规律性有氧运动影响成人血浆中IL-6浓度的随机对照实验(RCT),Cochrane偏倚风险评估工具评价纳入研究的方法学质量,Stata 13.0软件进行统计分析。结果:共纳入32个RCT,2 768个成年人,其中,慢性炎症性疾病患者670人。纳入研究中较高等级的方法学质量的研究有10个、中等研究质量12个、低等质量10个。Meta分析结果显示,规律性有氧运动可明显降低成年人血浆中IL-6浓度,SMD=-0.42(95%CI:-0.62^-0.18,P=0.001),但异质性较为明显(I2=88.1%)。通过Meta回归分析排除健康状态及其他可能的混杂因素影响后,异质性有所降低(I2=58.34%)。进一步的亚组分析结果提示,规律性有氧运动对健康成年人血浆IL-6浓度的降低效果不明显(SMD=-0.189,95%CI:-0.412~0.035,P=0.098),但对肥胖和炎症相关的慢性病患者的降低效果显著,其SMD(95CI%)分别为-0.593(-1.137^-0.05,P=0.032)和-0.717(-1.324^-0.123,P=0.021)。结论:规律性有氧运动能够有效降低成年人血浆中IL-6浓度,尤其对炎症性慢性病患者效果更为显著,但由于异质性和发表偏倚的影响,结论尚需开展更多高质量的研究加以验证。

Objective：To evaluate the effect of aerobatic exercise for plasma IL-6levels in adults.Methods：The randomized controlled trials（RCTs）of aerobatic exercise for plasma IL-6level in adults were identified from PubMed,Embase,Web of Science,Wanfang Data,CNKI and VIP Data（from inception to December,2014）.The methodological quality of included RCTs was assessed by the Cochrane collaboration＇s tool for assessing risk of bias.The Meta analysis was performed by using STATA 13.0software.Results：Among 32 included RCTs involving 2 768adults（of them,including 670 patients with chronic inflammatory diseases）,10 RCTs were graded as high methodological quality,12 graded as moderate degree,and other10 as low degree of methodological quality.The pooled result showed that aerobatic exercises were benefit to decrease plasma IL-6levels in adults,and the SMD=-0.42（95%CI：-0.62^-0.18,P=0.001）,but the heterogenicity was substantive with I2=88.1%.The heterogenicity was decreased to 58.34% by adjusted for the possible bias factors such as the participants＇ health status,the average of age,the type of comparison between groups,the duration of aerobatic exercise and quality of study by using Meta regression.The sub-group analysis suggested that effect of aerobatic exercise decreasing plasma IL-6levels was more effective in patients with chronic inflammatory diseases or the obese individuals than the healthy adults,and SWD（95%CI）was-0.717（-1.324^-0.123,P=0.021）,-0.593（-1.137^-0.05,P=0.032）and-0.189（-0.412~0.035,P=0.098）,respectively.Conclusion：Current evidence shows that regular aerobatic exercises are effective to decrease plasma IL-6levels in adults,especially in patients with chronic inflammatory diseases.However,more highquality studies are required to verify the conclusion of this study due to the obvious heterogenicity and publication bias.