老年正常人与原发性高血压患者抗高血压因子活性的比较

Comparison of antihypertensive factor from erythrocytes of normotensive senior citizens with senior essential hypertensives

目的 研究老年人抗高血压因子 (AHF)的变化情况。方法 从正常老年人和老年原发性高血压Ⅰ期患者的红细胞中提取出AHF ,以肾性高血压大鼠为模型行急性降压实验。结果 正常老年人及老年原发性高血压患者的红细胞中均含有AHF ,且均具有显著的降压和减慢心率作用 ;正常老年人及经治疗后血压正常的老年原发性高血压患者AHF的综合活性指标分别为 117 4和 119 5 ,两者差异无显著性 (P >0 0 5 ) ,且均显著高于未经治疗的老年原发性高血压患者 (5 6 2 )和经治疗血压仍异常的老年原发性高血压患者 (5 0 5 )的AHF活性 (P <0 0 5 ) ;不论正常老年人还是老年原发性高血压患者 ,血压水平都与其AHF的活性呈明显的负相关 (r为负值 ,|r| >0 72 ,P <0 0 1)。结论 AHF活性降低可能是老年人高血压发展的重要原因之一。

Objective To study the level of antihypertensive factor(AHF) from erythrocytes of senior citizens. Methods AHF was extracted from erythrocytes of normotensive senior citizens(NSC) and senior essential hypertensives(SEH), and the acute depressive experiments of AHF on model of renal hypertensive rat(RHR) were undertaken. Results AHF presented in erythrocytes of both NSC and SEH, and both had significant effects of depression and heart rate lowering. The integrated effective index of AHF is 117 4 in NSC, and is 119 5 treated SEH with normal blood pressure. There was no significant difference( P <0 05), and both of them were higher than that of AHF from untreated SEH with high blood pressure(56 2) and treated SEH with high blood pressure(50 5)( P <0 05). The level of blood pressure was negatively correlated with the effects of AHF in bith NSC and SEH( r is negative, | r |>0 72, P <0 01). Conclusion AHF deficiency may play an important role in the development of senior essential hypertension.