卵巢恶性肿瘤的临床病理分期、肿瘤的组织分类与子宫内膜异位症发生的关系研究

Study on the relationship between clinicopathological staging,histological classification of ovarian malignant tumor and endometriosis

目的观察卵巢恶性肿瘤临床病理分期、肿瘤组织分类和子宫内膜异位症的关系。方法选择在医院接受治疗的原发性卵巢恶性肿瘤患者200例,其中患有子宫内膜异位症的患者分为观察组,未患有子宫内膜异位症的患者分为对照组,分析两组患者临床的病理分期、肿瘤组织分类等情况。结果观察组在Ⅰ期的患者较多达到了72.8%,对照组在Ⅲ期患者较多达61.2%,两组患者恶性肿瘤分期差异有统计学意义(P<0.05);观察组59.1%为内膜样癌患者,对照组36.5%为内膜样患者,两组患者的内膜样癌和透明细胞癌比较差异有统计学意义(P<0.05);内膜异位症患者在卵巢透明细胞癌中发生率较高达到了42.9%,明显高于其他肿瘤组织。结论组织的病灶程度和临床分期情况可能与卵巢内膜异位症恶变的诊断有关,内膜异位症的病灶恶变可能和卵巢内膜样癌、透明细胞癌有关。

Objective To observe the relationship between clinicopathological staging, histological classification of ovarian malignant tumor and endometriosis. Methods Two hundred primary ovarian malignant tumor patients treated in the hospital were selected and divided into observation group （with endometriosis） and control group （without endometriosis） ; clinicopathological staging and histological classification of patients in the two groups were analyzed. Results In observation group, the proportion of patients of stage I was as high as 72. 8% ; in control group, the proportion of patients of stage m was as high as 61.2%, there was statistically significant difference in clini-copathological staging between the two groups （P〈0. 05） ; in observation group, 59. 1% of the patients were diagnosed as endometrioid carcinoma, while in control group, the proportion was 36. 5% ; there were statistically significant differences in the proportions of patients with ovarian endometrioid carcinoma and clear cell carcinoma between the two groups （P〈0.05） ; among the patients with ovarian clear cell carci-noma, 42.9% of them were found with endometriosis, which was significantly higher than the patients with other tumor tissues. Conclusion The degree of tissue lesions and clinical staging may be related to malignant transformation of ovarian endometriosis ; malignant transformation of ovarian endometriosis may be correlated with endometrioid carcinoma and clear cell carcinoma.