ICP-MS法同时测定感冒灵颗粒中9种金属元素的含量

Simultaneous Determination of the Contents of 9 Metal Elements in Ganmaoling Granule by ICP-MS

目的：建立同时测定感冒灵颗粒中铜、铅、砷、铬、镉、钡、锰、锑、汞等9种金属元素含量的方法。方法：样品加硝酸微波消解后,采用电感耦合等离子体质谱（ICP-MS）法进行同时测定,以锗、铟、铋元素作为内标,以待测元素标准品作为标准物质,射频功率为1 100 W,采样深度为8 mm,载气为高纯氩气,载气流量为1.0 L/min。结果：9种金属元素在各自的质量浓度范围内与仪器响应值之比呈良好的线性关系（r为0.999 1～0.999 9）;检测限在0.3～6.0μg/L之间;精密度、稳定性、重复性试验的RSD≤6.0%;加样回收率为80.0%～113.5%,RSD为1.0%～4.5%。结论：该方法简单、快速、准确,可用于感冒灵颗粒中9种金属元素的含量测定。

OBJECTIVE： To establish a method for simultaneous determination of the contents of Cu, Pb, As, Cr, Cd, Ba, Mn, Sb and Hg in Ganmaoling granule. METHODS ： ICP-MS was conducted. The sample was handled by nitric acid microwave di- gestion system, the mass concnetration of 9 metal elements were determined by ICP-MS with Ge, In, Bi as internal standard and standard substance of test element standards. RF power was 1 100 W, sampling depth was 8 mm, carrier gas was argon （Ar） with high purity and flow rate was 1.0 L/min. RESULTS：All 9 elements bad good linear range between mass concentration and ion peaks （r=0.999 1-0.999 9）, detection limits were in the range of 0.3-6.0 μg/L; RSDs of precision, stability and reproducibility tests were no more than 6.0%; average recoveries were in the range of 80.0%-113.5%, and RSDs were in 1.0%-4.5%. CONCLUSIONS： The method is simple, rapid and accurate, and can be used for the determination of 9 metal elements in Ganmaoling granule.