HLA-DQ基因rs2856718A>G、rs9275572A>G多态性与慢性乙型肝炎发病风险相关性的Meta分析

Association between HLA-DQ Gene rs2856178A>G, rs9275572A>G Polymorphisms and the Risk of Chronic Hepatitis B: A Meta-analysis

目的系统评价人类白细胞抗原DQ(HLA-DQ)基因rs2856718A>G、rs9275572A>G多态性与慢性乙型肝炎发病风险的相关性。方法计算机检索PubMed、EMbase、CBM、WanFang Data、CNKI、和VIP数据库,搜集有关HLA-DQ基因多态性与慢性乙型肝炎发病风险相关性的病例-对照研究,检索时限均为从建库至2015年4月。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析,并采用Stata 12.0软件进行发表偏倚分析。结果最终纳入6篇文献,共计8个病例-对照研究,含3 690例病例,6 267例对照。Meta分析结果显示:rs2856718A>G多态性与慢性乙型肝炎发病风险降低相关[AG+GG vs.AA:OR=0.63,95%CI(0.51,0.78),P=0.000;GG vs.AG+AA:OR=0.69,95%CI(0.61,0.79),P=0.000;GG vs.AA:OR=0.56,95%CI(0.48,0.64),P=0.000;GA vs.AA:OR=0.64,95%CI(0.47,0.88),P=0.006;G vs.A:OR=0.74,95%CI(0.68,0.79),P=0.000]。rs9275572A>G多态性与慢性乙型肝炎的发病风险无相关性[AG+GG vs.AA:OR=1.11,95%CI(0.55,2.23),P=0.770;GG vs.AG+AA:OR=1.10,95%CI(0.84,1.45),P=0.500;GG vs.AA:OR=1.14,95%CI(0.54,2.41),P=0.730;AG vs.AA:OR=1.06,95%CI(0.56,2.02),P=0.860;G vs.A:OR=1.11,95%CI(0.83,1.48),P=0.490]。结论 HLA-DQ基因rs2856718A>G多态性与慢性乙型肝炎发病风险降低相关,而rs9275319A>G多态性与慢性乙型肝炎发病风险不相关。

Objective To systematically evaluate the association between human leukocyte antigen DQ （HLA-DQ） gene rs2856718A〉G, rs9275572A〉G polymorphisms and the risk of chronic hepatitis B. Methods PubMed, EMbase, CBM, WanFang Data, CNKI and VIP databases were systematically searched from inception to April 2015 to collect case- control studies about HLA-DQ gene polymorphisms and the risk of chronic hepatitis B. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software, and Stata 12.0 software was used for sensitivity and publication bias analysis. Results A total of 6 papers involving 8 case-control studies were included, which involved 3 690 cases and 6 267 controls. The results of meta-analysis showed that： the rs2856718A〉G polymorphism was associated with the decreased risk of chronic hepatitis B （AG＋GG vs. AA： OR=0.63, 95%CI 0.51 to 0.78, P=0.000; GG vs. AG＋AA： OR=0.69, 95%CI 0.61 to 0.79, P=0.000; GG vs. AA： OR=0.56, 95%CI 0.48 to 0.64, P=0.000; GA vs. AA： OR=0.64, 95%CI 0.47 to 0.88, P=0.006; G vs. A： OR=0.74, 95%CI 0.68 to 0.79, P=0.000）. The rs9275572A〉G polymorphism was not associated with the risk of chronic hepatitis B （AG＋GG vs. AA： OR=1.11, 95%CI 0.55 to 2.23, P=0.770; GG vs. AG＋AA： OR=1.10, 95%CI 0.84 to 1.45, P=0.500; GG vs. AA： OR=1.14, 95%CI 0.54 to 2.41, P=0.730; AG vs. AA： OR=1.06, 95%CI 0.56 to 2.02, P=0.860; G vs. A： OR=1.11, 95%CI 0.83 to 1.48, P=0.490）. Conclusion HLA-DQ gene rs2856718 A〉G polymorphism is significantly associated with decreased risk of chronic hepatitis B, but the rs9271319 A〉G polymorphism is not associated with the risk of chronic hepatitis B.