低氧与运动训练对线粒体自噬影响的研究进展

Effects of Hypoxia and Exercise Training on Mitophagy

线粒体是机体主要的供能细胞器,但是氧化损伤等因素会导致线粒体功能失调.研究表明,自噬是线粒体维持自身数量以及质量的动态平衡的主要方式之一.线粒体自噬(mitochondrial autophagy)具有选择性,对受损伤或不需要的线粒体能特异性识别,由自噬体将其包裹并清除.线粒体自噬对维持细胞内环境稳态具有重要意义,是维持整个线粒体网络功能完整性和细胞生存的重要机制之一.运动训练对机体代谢的良性效应可用自噬现象来解释,细胞自噬已成为当前运动科学领域的研究热点.该文主要综述近年来国内外有关低氧与运动训练对线粒体自噬现象影响的研究进展.

Mitochondria is the main energy supply organelle of body.Its normal function is an important guarantee for energy of the normal body.But reactive oxygen species and hunger can lead to mitochondrial dysfunction.This paper showed mitochondria mainly rely on autophagy to maintain their quantity and quality of homeostasis.Mitophagy is a selective autophagy pathway,specific recognition beyond repair mitochondria,and wrapped into autophagy,the process could be cleared by the lysosomes.It is important to maintain cell homeostasis,it is one of the important factors in maintaining the functional integrity of the entire mitochondrial network and cell survival.In 2012,Garber pointed out,the sound effect of exercise training on metabolism can be used to explain the phenomenon of autophagy,subsequently,autophagy becomes a hot topic in the field of exercise science.This paper reviews the recent development related to effect of hypoxia and training on mitochondrial autophagy.