肝脏因子在2型糖尿病中的作用

The Role of Hepatokines in Type 2 Diabetes Mellitus

大量实验研究表明,肝脏脂肪堆积与2型糖尿病(T2DM)的发展有关。在非酒精性脂肪肝(NAFLD)患者体内存在葡萄糖及脂代谢的紊乱,而目前已知一些仅由肝脏或主要由肝脏分泌的蛋白质直接影响葡萄糖及脂代谢,与脂肪因子和肌肉因子类似,这些蛋白质被称为肝脏因子。包括第一个被发现的肝脏因子胎球蛋白A在内,这些肝脏因子在能量代谢以及胰岛素敏感性的调节中发挥着重要作用,研究它们在T2DM中的作用将为治疗T2DM提供新的思路。

A large quantity of experiments have demonstrated that the fatty liver is associated with type 2 diabetes mellitus（T2DM）. In patients of nonalcoholic fatty liver disease（NAFLD）,there is dysregulated glu-cose and lipid metabolism. Additionally,several proteins that are exclusively or predominantly secreted from liver are now known to directly affect glucose and lipid metabolism. Similar to the adipokines and myokines, these liver-derived proteins are known as hepatokines. Including the first hepatokine-fetuin-A, the hepato-kines have important roles in regulating energy metabolism and insulin sensitivity. The studies of hepatokines in T2DM will provide a new treatment idea.