心脏X综合征发病机制及治疗的研究进展

Research Progress of Pathogenesis and Treatment for Cardiac Syndrome X

心脏X综合征患者通常具有心绞痛或类似心绞痛的症状,心电图及运动平板试验出现ST段压低,而冠状动脉造影却完全正常。本病多见于围绝经期的妇女,会影响患者的生活质量,并且在一些特定的患者中预后较差。传统的抗心绞痛治疗方法的疗效有限(如硝酸酯类药物、钙离子拮抗剂及尼可地尔等),与本病病因不明、治疗仅限于对症有关。因此,明确本病病因,根据病因给予相应治疗,是目前急需解决的问题。

The patients of cardiac syndrome X（ CSX） usually have symptoms of angina or angina-like thoracalgia,ST segment depression in ECG or treadmill test,along with normal coronary angiogram. CSX is most typically seen in perimenopausal women. The condition can impair the patient′s quality of life,and is associated with an adverse prognosis in certain patient subgroups. Conventional therapies with antianginal agents such as nitrates,calcium channel antagonists,and nicorandil have been tried,with limited efficacy. However,this might be related to a failure to target the underlying pathophysiology. Therefore,figuring out the pathogenesis and then giving the treatment accordingly,is the priority now.