高加索人种IL-1β+3953位点基因多态性与肺结核易患性关系的Meta分析

Association between Interleukin 1β gene + 3953 Polymorphism and Tuberculosis Susceptibility in Caucasian Population: A Meta-analysis

目的：探讨高加索人种白细胞介素（IL）1β＋3953位点基因多态性与肺结核易患性关系。方法计算机检索数据库,收集有关高加索人种IL-1β＋3953位点基因多态性与肺结核病易患性关系病例对照研究,提取纳入文献的相关数据进行Meta分析,以病例组与对照组IL-1β＋3953位点各种基因模型的比值比为效应指标。结果共6篇研究符合纳入标准,累计病例数1024例,对照组995例。 Meta分析表明,IL-1β＋3953位点基因多态性与肺结核病易患性无明显关联性（ CC比TT：OR=0．66,95%CI 0．40-1．09,P=0．11；TC比TT：OR=0．94,95%CI 0．75-1．18,P=0．59；CC＋TC比TT：OR=0．89,95%CI 0．72-1．10,P=0．30；CC 比 TC＋TT：OR=0．66,95%CI 0．40-1．07,P=0．09）。结论高加索人种IL-1β＋3953位点基因多态性与肺结核病易患性无明显关联性。

Objective To explore the association between the interleukin 1β（ IL-1β） gene ＋3953 pol-ymorphism and tuberculosis susceptibility in Caucasian population. Methods Data bases were comprehen-sively searched to retrace all the related studies on the associations between IL-1β gene ＋3953 polymor-phism and tuberculosis susceptibility in European population. The related data were extracted from the litera-ture to carry on the Meta-analysis. The pooled odds ratios（ ORs） of the association between IL-1βgene＋3953 polymorphism and tuberculosis susceptibility in Caucasian population were performed in different genetic model comparison. Results Altogether 6 original studies with a total of 2019 subjects（1024 patients and 995 controls） were entered the final data combination. The results of Meta-analysis showed that there were no significant associations between IL-1β gene ＋3953 polymorphism and tuberculosis susceptibility in Cauca-sian population [CC vs TT：OR=0. 66,95%CI 0. 40-1. 09,P=0. 11;TC vs TT：OR=0. 94,95%CI 0. 75-1. 18,P=0. 59;CC＋TC vs TT：OR=0. 89,95%CI 0. 72-1. 10,P=0. 30;CC vs TC＋TT：OR=0. 66,95%CI 0. 40-1. 07,P=0. 09]. Conclusion There are no significant associations between IL-1β gene ＋3953 polymorphism and tuberculosis susceptibility in Caucasian population.