LRP、GST-π表达与卵巢癌化疗耐药及预后的关系

The correlations of LRP and GST-π to chemotherapy resistance and prognosis of ovarian cancer

目的 探讨肺耐药蛋白（LRP）、谷胱甘肽S转移酶π（GST-π）表达与上皮性卵巢癌铂类化疗耐药及患者预后的关系.方法 上皮性卵巢癌患者66例采用免疫组化法检测其LRP、GST-π表达,分析LRP、GST-π表达与化疗疗效及术后生存时间的关系.结果 LRP和GST-π阳性表达者近期化疗有效率显著低于阴性者[61.2％、61.7％ vs 94.1％、89.5％,x2=6.47,4.94,P=0.011,P=0.026];化疗耐药组中LRP和GST-π阳性表达率明显高于化疗敏感组[91.3％、87.0％ vs 65.1％,62.8％,P＜0.05].Log-rank检验表明,LRP、GST-π阳性者较阴性者术后生存时间短,LRP和GST-π共阳性者较共阴性者术后生存时间短（P＜0.05）.结论 LRP和GST-π可作为预测上皮性卵巢癌化疗耐药及患者预后的重要指标.

Objective To explore the correlations of lung resistance protein （LRP） and glutathione S transferase π （GST-π） to chemotherapy resistance and prognosis of epithelial ovarian cancer.Methods The expressions of LRP and GST-π in epithelial ovarian cancer were examined with immunohistochemistry.Correlations of LRP and GST-π to chemotherapy efficacy and survival time after operation were analyzed.Results The short-term efficacy rates of ovarian cancer were lower in patients with positive expressions of LRP and GST-π than those with negative expressions [61.2%,61.7% vs 94.1%,89.5%,x2 =6.47,4.94,P =0.011,P =0.026].The positive rates of LRP and GST-π were significant higher in patients with chemotherapy resistance than in those sensitive to chemotherapy [91.3%,87.0% vs 65.1%,62.8%,P 〈 0.05].Log-rank test showed that patients with positive LRP and GST-π had shorter survival time than those negative,and patients with both positive LRP and GST-π had shorter survival time than those both negative （P 〈 0.05）.Conclusions The expressions of LRP and GST-π in epithelial ovarian cancer could be used to predict chemotherapy resistance and prognosis of patients.