陕北地区丙型肝炎病毒基因型对抗病毒治疗的影响

Effect of genetype of hepatitis C virus on treatment in Northern Shanxi area

目的了解陕北地区丙型肝炎病毒(HCV)基因型流行状况,探讨HCV基因型对抗病毒治疗的影响。方法对丙型肝炎患者的血清进行HCV RNA定量及基因型检测,采用实时荧光定量聚合酶链反应(FQ-PCR)方法结合Taqman技术;对聚乙二醇化干扰素α2a(PEG-IFNα-2a)与干扰素α-2b治疗24周结束时,取得病毒学应答(RVR)的丙型肝炎患者进行24周随访观察。结果在85例HCV RNA阳性的患者中,基因1型30例(35.3%),实现RVR的患者有25例(83.3%),复发有7例(23.3%);非1型55例(64.7%),其中全部实现RVR,复发有4例(7.3%)。结论病毒基因型与丙型肝炎干扰素治疗后的病毒复发有显著相关性。

Objective To understand hepatitis C virus（HCV）genotype in Northern Shanxi prevalence and explore the effect of HCV genotype to antiviral therapy.Methods HCV RNA quantitative and genotypes of patients with hepatitis C were detected with real-time fluorescence quantitative polymerase chain reaction（FQ-PCR）method based on Taqman Technology.The patients were treated with pegylated interferon a 2a（PEG-IFN a-2a）and interferon a-2bfor 24 weeks.The patients with virological response were followed-up for 24 weeks.Results Of 85 cases with positive HCV RNA,there were 30 cases with 1genetype（35.3%）,25cases（83.3%）of them with RVR and 7cases（23.3%）with recurrence.There were 55cases（64.7%）with 1non type,all of them with RVR and 4cases（7.3%）with recurrence.Conclusions There is correlation between hepatitis C virus genotype and viral relapse after interferon treatment.