乙型肝炎肝硬化患者的负性情绪对血清ACTH、NPY的影响

Effect of Negative Emotions on Serum Levels of Adrenocorticotropic Hormones and Neuropeptide Y in Hepatitis B Liver Cirrhosis Patients

目的探讨乙型肝炎肝硬化患者的负性情绪对血清促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)及神经肽Y(neuropeptide Y,NPY)的影响。方法将617例乙型肝炎肝硬化患者按照负性情绪的判定方法分为负性情绪组(415例)和无负性情绪组(202例),记录两组患者Child-Pugh不同分级例数,比较两组患者肝功能情况;采用双抗体一步夹心法酶联免疫吸附试验(ELISA)检测两组患者血清ACTH、NPY水平。结果负性情绪组Child-Pugh分级与无负性情绪组比较,差异无统计学意义(x^2=0.65,P=0.72);与无负性情绪组比较,负性情绪组血清NPY水平明显降低,差异有统计学意义(P<0.05),两组ACTH水平比较,差异无统计学意义(P>0.05)。结论本研究纳入的乙型肝炎肝硬化患者的负性情绪与血清ACTH水平无关,与相对低浓度的血清NPY水平有关。

Objective To explore the effect of negative emotions on serum levels of adrenocorticotropic hormone（ACTH） and neuropeptide Y（NYP） in hepatitis B liver cirrhosis（HBLC） patients.Methods Totally 617 HBLC patients were assigned to the negative emotion group（415 cases） and the non-negative emotion group（202 cases） judged by negative emotions.Case numbers of various grading Child-Pugh were recorded in the two groups.Their liver functions were compared between the two groups.Serum levels of ACTH and NPY were detected using double antibody sandwich enzyme-linked immunosorbent assay（ELISA） in the two groups.Results There was no statistical difference in Child-Pugh grading between the two groups（x2=0.65,P=0.72）.Compared with the non-negative emotional group,serum ACTH levels decreased significantly in the negative emotion group with statistical difference（P〈0.05）.There was no statistical difference in serum ACTH levels between the two groups（P〉0.05）.Conclusion The negative emotion of HBLC patients was not related to the serum ACTH level,but to relatively lower-concentration serum NPY levels.