2型糖尿病患者亚临床甲状腺功能减退症与颈动脉粥样硬化的相关性研究

Relationship between subclinical hypothyroidism and carotid artery atherosclerosis in type 2 diabetes mellitus patients

目的探讨2型糖尿病(T2DM)患者亚临床甲状腺功能减退症(SCH)与颈动脉粥样硬化的相关性。方法选择2014年8月-2015年3月上海第九人民医院诊断为T2DM的患者138例,按是否合并颈动脉粥样硬化分为动脉粥样硬化组(76例)和非动脉粥样硬化组(62例),分析颈动脉粥样硬化的危险因素。结果单因素分析结果显示,促甲状腺激素(TSH)、收缩压(SBP)、低密度脂蛋白胆固醇(LDLC)、尿酸(UA)、同型半胱氨酸(Hcy)、总胆固醇(TC)、甘油三酯(TG)、D-二聚体(D-Dimer)、C型反应性蛋白(CRP)与动脉粥样硬化的发生相关(P<0.05,P<0.01),其余指标无显著相关性(P>0.05)。Logistic回归分析显示,TSH、SBP、LDLC、Hcy升高是颈动脉粥样硬化的危险因素(P<0.01)。结论 T2DM合并SCH易增加患者颈动脉粥样硬化的发生风险,且TSH是颈动脉粥样硬化的危险因素。

Objective To investigate the relationship between subclinical hypothyroidism（ SCH） and carotid artery atherosclerosis in type 2 diabetes mellitus（ T2DM） patients. Methods A total of 138 patients with T2 DM were selected in this research. All the patients were divided into carotid artery atherosclerosis group（ n = 76） and non-carotid artery atherosclerosis group（ n = 62）. The general clinic materials of two groups were compared to analyze hazards of carotid artery atherosclerosis. Results Univariate analysis showed that thyroid stimulating hormone（ TSH）,systolic blood pressure（ SBP）,low density lipoprotein（ LDLC）,uric acid（ UA）,homocysteine（ Hcy）,total cholesterol（ TC）,triglyceride（ TG） and D-Dimer and C reactive protein（ CRP） had relationships with atherosclerotic（ P 0. 05 or P 0. 01）,but had no correlation with other indicators（ P 0. 05）. Logistic analysis showed that the increase of TSH,SBP,LDLC and Hcy were risk factors of carotid artery atherosclerosis（ P 0. 01）. Conclusion T2 DM patients with SCH can increase the risk of the occurrence,and TSH is a risk factor of carotid artery atherosclerosis.