皱盖假芝水提物抑制单纯疱疹病毒研究

Effect of Aqueous Extracts of Amauroderma rudis Fruit Bodies on Herpes Simplex Virus Infection of Vero Cells in Vitro

研究了皱盖假芝(Amauroderma rudis)水提物(AERA)对单纯疱疹病毒(Herpes Simplex Virus,HSV)感染细胞的抑制效果。体外细胞试验结果表明:皱盖假芝水提物能有效抑制HSV感染非洲绿猴肾细胞(African green monkey kidney,Vero)(半数有效浓度IC50为107μg/mL),且具有低毒性优点(半数致死浓度CC50为1477μg/mL)。不同加样时间和加样顺序试验结果表明:水提物AEAR是作用于HSV病毒感染细胞的早期阶段。

Aqueous extracts of Amauroderma rudis fruit bodies （AEAR） inhibited type 1 herpes simplex virus （HSV-1） infection of Vero cells in vitro by 50% at 107μg/mL concentration. The CC50 value of AEAR for Vcro cells was 1477 μg/mL. The inhibitory effects of AEAR occurred in the early stages of infection.