摘要
慢性鼻-鼻窦炎(CRS)是上呼吸道常见的慢性炎症性疾病,严重影响了患者生活质量,目前其发病机制尚不明确。CRS的动物模型是研究人类CRS病理机制和疗效的理想手段。小鼠是目前CRS常用的造模动物。就小鼠CRS的造模方法、模型评价指标及模型的应用现状等做研究综述。
Chronic rhinosinusitis（CRS）is a common chronic inflammatory disease of the upper respiratory tract,which seriously affects the patients’quality of life.Because of its uncertain pathogenesis,the curative effect is not satisfacto-ry.Animal model of CRS is the ideal means for study of the human CRS pathological mechanism and curative effect. Mice are currently common CRS animals.The main content of the review includes research progress of the mice CRS-building methods,the evaluation index and application status of the model.
出处
《山东大学耳鼻喉眼学报》
CAS
2015年第5期76-78,82,共4页
Journal of Otolaryngology and Ophthalmology of Shandong University
基金
国家自然科学基金(81371073)
广州市天河区科技计划项目(201409KW027)
关键词
慢性鼻-鼻窦炎
鼻息肉
动物模型
小鼠
文献综述
Chronic rhinosinusitis
Nasal polyps
Animal model
Mouse
Literature review
