硫酸镁联合硝苯地平治疗子痫前期的临床效果观察

Clinical Observation of Treatment Effect of Magnesium Sulfate Combined with Nifedipine on Preeclampsia

目的探讨并分析硫酸镁联合硝苯地平对子痫前期治疗的临床效果。方法选取2011年12月至2014年12月我院收治的经过确诊的72例子痫前期的患者,随机均分为两组,分别为对照组和观察组,每组各36例,仅给予对照组患者硫酸镁注射液治疗,而观察组患者则是在给予硫酸镁注射液的基础上联合硝苯地平一起进行治疗,观察并比较用药治疗前后患者血压水平的控制情况、全身水肿情况、尿液中蛋白的水平以及对自觉症状的治疗效果评价,并且对在治疗过程患者产生的不良情况进行统计。结果 72例患者的血压都得到了有效的控制,两组患者在治疗10 d后的蛋白尿水平、全身水肿情况以及对自觉症状方面观察组明显低于对照组(P<0.05),并且在治疗过程中并无严重不良反应出现。而且观察组达到显著有效的患者有19例,有效的患者16例,无效的仅为1例,总有效率达到了97.2%。而对照组达到显著有效的患者为14例,稍微有效的患者为15例,无效的患者有7例,总有效率为81%,总有效率观察组明显高于对照组。结论利用硫酸镁和硝苯地平联合治疗子痫前期患者有很好的临床治疗效果,明显优于单一使用硫酸镁治疗的效果,值得在临床上推广,得到更为广泛的应用。

Objective To investigate and analyze the clinical effect of magnesium sulfate combined with nifedipine on preeclamp- siab syndrome. Methods 72 cases of patients who were admitted into our hospital and diagnosed with preeclampsia syndrome from December 2011 to December 2014 were selected and randomly divided into two groups： control group and observation group, with 36 cases in each one. The control group was treated with magnesium sulfate injection alone, while the observation group was given magne- sium sulfate injection combined with nifedipine. The control level of blood pressure, degree of anasarca, protein level in the urine, and therapeutic effect evaluation of rational symptom before and after treatment were observed and compared. Besides, the untoward effects of those patients during the treatment were also recorded. Results 72 cases of patients＇ blood pressure was brought under effective control. After 10 days＇ treatment, the degree of anasarca, protein level in the urine, and therapeutic effect evaluation of rational symp- tom of the observation group were significantly better than those of the control group （ P 〈 0. 05 ） , and without any serious side effect during the treatment. In the observation group, there were 19 patients with significantly effective treatment, 16 with effective treatment, and only 1 with ineffective treatment, with a total effective rate of 97.2%. And in the control group, there were 14 patients with signif- icantly effective treatment, 15 with slightly effective treatment, 7 with ineffective treatment, with a total effective rate of 81%. The conclusion was that the total effective rate of the observation group was significantly higher than that of the control group. Conclusion Magnesium sulfate combined with nifedipine proves to be more effective on preeclampsia than magnesium sulfate alone, worthy to he promoted and applied in the clinic therapy.