炎症反应、热性惊厥与继发性癫痫相关性研究进展

The progress of research in association of inflammatory and febrile seizures with secondary epilepsy

热性惊厥(FS)是婴幼儿及学龄前儿童最常见的一种惊厥表现形式。炎症递质作为发热触发因子,也被认为参与了此类惊厥的发生。有证据表明,FS伴随炎症反应而发生,而炎症递质在长时程FS后癫痫发生中的潜在作用尚未完全确定。文章从炎症反应、热性惊厥以及继发性癫痫发生几方面进行综述,探讨近期国内外对于三者之间相互作用的研究进展。

Febrile seizure（FS） is the most common type of seizures in infants, toddler, and preschool children. Inflammatory mediators as triggers of fever are considered to be involved in the occurrence of such seizures. There is evidence that FS is accompanied by inflammation. The potential role of inflammatory mediators in the development of epilepsy after long term FS has not been fully determined. In this article the inflammatory reaction, febrile convulsion, and the occurrence of secondary epilepsy will be reviewed. The progress in research of the interaction among them at home and abroad will be explored.