婴儿促纤维增生型星形细胞瘤的MR表现和病理学特点(附1例报告)

MR and pathological features of desmoplastic infantile astrocytoma( report of 1 case)

目的探讨婴儿促纤维增生型星形细胞瘤(DIA)的MR表现和病理学特点。方法回顾性分析1例DIA患者的临床、MR和病理学资料。结果本例为1岁男婴。MR表现为右额叶囊实性肿块,实性部分表浅贴近脑膜生长,强化明显,囊性部分较大,无强化。病理组织学表现在增生的灶状或巢状排列的纤维性间质中包含有向星形细胞分化的神经上皮成分,免疫组化GFAP、S-100蛋白和Vim阳性表达,Syn和EMA染色呈阴性。结论 DIA在MR上的特征性表现为病变位置表浅且贴近脑膜,病理学特征为灶状或巢状排列的纤维性间质中包含有向星形细胞分化的神经上皮成分,明确诊断仍需依靠病理学检查。

Objective To study the MR and pathological features of desmoplastic infantile astrocytoma（ DIA）.Methods The clinical MR and pathological data of a DIA patient was retrospectively analyzed. Results This case was one year old boy. MR showed a cystic and solid portion within tumor of the right frontal lobe,solid portion with dura mater adherent enhanced obviously,cystic portion was larger,no enhancem-ent. The pathological histology performance was the neural epithelium differentiation to the astrocytes in the hyperplasia fibrous stroma with multifocal or nests arrangement. Immunohistochemistry showed that the tumor cells were positive for GFAP,S-100 and Vim,but negative for synaptophysin and EMA. Conclusions The MR feature of DIA is that thelesion location is shallow and close to the dura mater. The pathological feature of DIA is the neural epithelium differentiation to the astrocytes in the hyperplasia fibrous stroma with multifocal or nests arrangement. Definite diagnosis still depends on pathological examination.