MiRNA与肿瘤相关巨噬细胞

MiRNA and tumor associated macrophages

肿瘤相关巨噬细胞(TAM)是由血液循环中的单核细胞募集进入肿瘤微环境后分化而成的巨噬细胞,它与肿瘤的形成、发展、侵袭和转移密切相关。miRNA是一种内源性非编码小分子RNA,参与多种肿瘤的发生、发展进程。研究表明,特定miRNA在控制TAM的极化方向和功能表型中发挥重要作用,有可能成为抗肿瘤靶向治疗的潜在分子靶点。本文综述了本领域的研究新进展。

Tumor associated macrophages （TAMs） which are correlated with the development, progression, invasion, migration and metastasis of tumor cell, differentiate from peripheral blood monocytes that migrate into the tumor microenvironment. MiRNAs are short endogenous nucleotide non-coding RNA sequences. And they participate in the development and progression of many tumors. Recent studies have revealed that specific miRNAs play important roles in the polarization and phenotype of TAMs. They may provide a possible molecular target for anti-tumor targeted therapy. This review will focus on the recent research progresses in this field.