肿瘤干细胞表面标志物及主要信号通路

Surface Makers and Principle Signaling Pathways of Cancer Stem Cells

肿瘤干细胞是存在于肿瘤组织中的具有自我更新、增殖、分化的部分细胞群,对肿瘤的发生、发展有十分重要的作用.肿瘤干细胞特异的表面分子及其异常活化的信号通路,是其区别于其他肿瘤细胞的特性.寻找和鉴定特异的肿瘤干细胞的表面标志物,从而识别肿瘤组织中的肿瘤干细胞,并进行相关信号调控机制研究,是肿瘤早期诊断及肿瘤干细胞靶向治疗的关键.本文简要概述了肿瘤干细胞相关的表面标志物及信号通路的研究进展,旨在为进一步开展针对肿瘤干细胞的抗体靶向治疗提供新思路.

Cancer stem cells（ CSCs）,also known as tumor initiating cells,are a small subset of tumor cells with the biological characteristics that are similar to those of normal stem cell including self-renewal and differentiation. CSCs are important for cancer occurrence and development. The specific surface markers and abnormal active signal pathways is different from other cancer cells. Finding and identifying the specific surface markers and understanding the related regulatory mechanisms of CSCs behaviors is crucial to developing the new strategies for cancer targeted and personalized therapies in the future. To give a new insight aiming at antibody therapeutics that target CSCs,in this paper,we summarized the current known surface markers and signal pathways.