麝香舒活灵的渗漉提取工艺优选

Optimization of Percolation Extraction Process of Shexiang Shuhuoling

目的:优选麝香舒活灵的渗漉提取工艺,为该制剂的工业化生产工艺改进提供参考。方法:在单因素试验基础上,以梓醇转移率及含固量为综合评价指标,乙醇体积分数、乙醇用量、渗漉速度、药材浸渍时间为考察因素,采用L9(34)正交试验优选麝香舒活灵的渗漉提取工艺。结果:最佳提取工艺条件为加15倍量50%乙醇浸渍6 h,流速0.25 m L·min-1。羟基红花黄色素A和梓醇的转移率分别为97.50%,102.07%,RSD分别为5.4%,3.5%。结论:该工艺提取率及有效成分转移率高,简单易行,适合麝香舒活灵的工业化大生产。

Objective： To optimize percolation extraction process of Shexiang Shuhuoling,and provide a reference for process improvement of this preparation in industrial production. Method： Based on single factor test,with composite score of transferring rate of catalpol and solid-containing content as index, orthogonal experimental design was adopted to optimize percolation extraction process by taking percolation rate,immersion time,ethanol concentration and amount as factors. Result： Optimum percolation extraction process was added 15 times the amount of 50% ethanol for immersing 6 h,percolation rate of 0. 25 m L·min-1. Transferring rates of hydroxy safflower yellow A and catalpol were 97. 50% and 102. 07% with RSD of 5. 4% and 3. 5%,respectively.Conclusion： This process is feasible and economical, which is suitable for industrial production of Shexiang Shuhuoling.