瓦山安息香树皮中四氢呋喃型木脂素类成分

Tetrahydrofuranoid Lignans from Stem Bark of Styrax perkinsiae

目的:研究瓦山安息香树皮中木脂素类成分。方法:采用反复硅胶柱色谱和葡聚糖凝胶柱色谱的色谱方法结合波谱方法分离鉴定瓦山安息香树皮的化学成分。结果:从瓦山安息香树皮提取物的醋酸乙酯萃取部位和三氯甲烷部位中分离得到8个四氢呋喃型木脂素类化合物,1个苯并呋喃型木脂素和1个丁烷型木脂素。根据化合物的波谱数据鉴定化合物的结构为(-)-(2R,3R)-secoisolariciresinol(1),2R,3S-dihydrodehydrodiconiferyl alcohol(2),罗汉松脂醇(3),(±)-salicifoliol(4),(-)-epipinoresinol(5),lariciresinol-4'-monomethy ether(6),(+)-pinoresinol monomethy ether(7),piperitol(8),styraxin(9),1R,2R,5S,6R-2-(4'-hydroxy-3'-methoxyphenyl)-6-(3″,4″-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane 4'-O-β-D-glucopyranoside(10)。结论:6个化合物(1,4,6,7,8,10)首次从安息香属植物中分离的得到。

Objective： To study the lignans components in the stem bark of Styrax perkinsiae. Method：The chemical components in the stem bark of S. perkinsiae were isolated and identified by repeated chromatography on silica gel column, sephadex gel filtration chromatography and spectral methods. Result： Eight tetrahydrofuranoid lignans,one benzofuranoid lignan,and one dibenzyl butane lignan were isolated from Et OAc fraction and CHCl3 fraction of the stem bark of S. perkinsiae and identified as following：（-）-（ 2R,3R）-secoisolariciresinol（ 1）,2R,3S-dihydrodehydrodiconiferyl alcohol（ 2）,matairesionol（ 3）,（ ±）-salicifoliol（ 4）,（-）-epipinoresinol（ 5）,lariciresinol-4＇-monomethy ether（ 6）,（ ＋）-pinoresinol monomethy ether（ 7）,piperitol（ 8）, styraxin（ 9）, 1R, 2R, 5S, 6R-2-（ 4＇-hydroxy-3＇-methoxyphenyl）-6-（ 3″, 4″-dimethoxyphenyl）-3, 7-dioxabicyclo [3. 3. 0 ] octane 4＇-O-β-D-glucopyranoside（ 10）. Conclusion： Six compounds（ 1,4,6,7,8,10） were isolated from the plants of Styrax for the first time.