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丹红注射液联合氯吡格雷治疗不稳定性心绞痛 被引量:5

Effect of Danhong Injection Combined with Clopidogrel in Treating Patients with Unstable Angina Pectoris
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摘要 目的:探讨丹红注射液联合氯吡格雷治疗不稳定性心绞痛(unstable angina pectoris,UAP)的临床疗效及对患者血脂和炎性因子的影响。方法:采用随机数字表法将于滨州市人民医院接受治疗的142例符合纳入标准的UAP患者分为对照组(n=72)和观察组(n=70)。在常规治疗的基础上,对照组给予氯吡格雷治疗,观察组在对照组治疗的基础上联合应用丹红注射液治疗。比较两组患者的临床疗效,总胆固醇(total cholesterol,TC),甘油三酯(triglyceride,TG),低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C),高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平,肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α),白细胞介素-1(interleukin-1,IL-1),白细胞介素-6(interleukin-6,IL-6)水平变化及不良反应发生情况。结果:观察组的治疗有效率为95.7%,明显高于对照组的总有效率84.7%(P<0.05),血瘀证型治疗总有效率高达92.9%,明显高于对照组的总有效率73.6%(P<0.05)。与对照组相比,观察组治疗后血脂指标TC[(4.60±0.24)VS(5.12±0.32)mmol·L-1],TG[(1.82±0.32)VS(2.41±0.27)mmol·L-1],LDL-C[(2.61±0.34)VS(3.36±0.33)mmol·L-1]水平显著降低,HDL-C[(1.71±0.22)VS(1.35±0.23)mmol·L-1]水平明显升高,炎性因子TNF-α[(54.21±9.57)VS(65.34±9.27)ng·L-1],IL-1[(0.28±0.09)VS(0.45±0.11)ng·L-1]和IL-6[(6.28±3.24)VS(9.55±3.64)ng·L-1]的水平显著降低,比较差异均有统计学意义(P<0.05)。治疗过程中,均未出现严重不良反应,观察组和对照组不良反应发生率分别为8.6%和11.1%,组间比较差异无统计学意义。结论:丹红注射液联合氯吡格雷是UAP的有效治疗方案,可以显著提高临床疗效和改善血脂水平,并减轻炎性反应,临床上值得进一步研究。 Objective: To investigate the clinical effect of Danhong injection in combination with clopidogrel in the treatment of patients with unstable angina pectoris( UAP) and its effects on level of blood lipids and inflammatory factors. Method: The 142 cases of eligible UAP patients treated in our hospital were randomly divided into the control group( n = 72) and the observation group( n = 70). Besides conventional treatments,the control group was also treated with clopidogrel,while the observation group was also treated with Danhong injection combined with clopidogrel. Then,the curative efficacy,total cholesterol( TC),triglyceride( TG),low density lipoprotein cholesterol( LDL-C), high density lipoprotein cholesterol( HDL-C), tumor necrosis factor-α( TNF-α),interleukin-1( IL-1),interleukin-6( IL-6) and adverse reactions of the two groups were compared.Result: The observation group had a therapeutic efficiency ratio of 95. 7%,which was significantly higher than that of 84. 7% in the control group( P〈0. 05). The observation group had a therapeutic efficiency ratio of 92. 9%on blood stagnaton type,which was significantly higher than that of 73. 6% in the control group( P〈0. 05).Compared with the control group,after the treatment,levels of total cholesterol [TC,( 4. 60 ± 0. 24) VS( 5. 12 ±0. 32) mmol·L-1],triglyceride [TG,( 1. 82 ± 0. 32) VS( 2. 41 ± 0. 27) mmol·L-1],low density lipoprotein cholesterol,[LDL-C,( 2. 61 ± 0. 34) VS( 3. 36 ± 0. 33) mmol·L-1] were respectively statistically lower and levels of density lipoprotein cholestero [HDL-C,( 1. 71 ± 0. 22) VS( 1. 35 ± 0. 23) mmol·L-1]was statistically higher in the observation group( P〈0. 05). As for inflammatory factors,levels of tumor necrosis factor-α[TNF-α,( 54. 21 ± 9. 57) VS( 65. 34 ± 9. 27) ng·L-1],interleukin-1 [IL-1,( 0. 28 ± 0. 09) VS( 0. 45 ±0. 11) ng·L-1]and IL-6 [( 6. 28 ± 3. 24) VS( 9. 55 ± 3. 64) ng·L-1]were statistically lower in the observation group than those in the control group after the treatment( P〈0. 05). During the treatment,there was no case of severe adverse reaction. The incidence of adverse reaction in the observation group was 8. 6%,which was statistically the same with that of 11. 1% in the control group. Conclusion: The combined administration of Danhong injection with clopidogrel for treating UAP is effective,which can significantly increase the curative efficiency,improve level of blood lipids and alleviate inflammatory reaction with minor adverse reaction,and is worth further studing in clinic.
出处 《中国实验方剂学杂志》 CAS CSCD 北大核心 2015年第20期171-174,共4页 Chinese Journal of Experimental Traditional Medical Formulae
基金 国家自然科学基金青年科学基金项目(81102840)
关键词 丹红注射液 氯吡格雷 不稳定性心绞痛 血脂 肿瘤坏死因-α 白细胞介素-6 Danhong injection clopidogrel unstable angina pectoris blood lipids tumor necrosis factor-α interleukin-6
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