醒脑静治疗中风的系统综述/Meta分析的方法学质量评价

Methodological Quality Assessment of Systematic Review / Meta Analysis of Xingnaojing in Treating Stroke

目的:评价国内醒脑静治疗中风的系统综述/Meta分析的方法学质量。方法:检索中国生物医学文献期刊,中国知网,维普,万方和Cochrane数据库,纳入醒脑静治疗中风的系统综述/Meta分析,检索时限截至2015年1月。采用OxmanGuyatt Overview Assessment Questionnaire(QQAQ)量表对纳入的Meta分析文献,Meta分析中的原始文献的方法学与报告质量进行评价与分析。结果:一共纳入13篇文献。纳入的Meta分析文献存在以下问题:文献检索不全面、选择性偏倚控制不佳、原始文献方法学质量评价不标准和准确性不高。Meta分析中原始文献的设计主要存在以下缺陷:随机方法不明,分组隐蔽不明确,没有采用盲法,失访或意向性分析报告、玷污或联合干扰描述不详细。结论:国内醒脑静治疗中风的系统评价/Meta分析的文献质量不甚理想,需进一步提高方法学水平和规范实验设计,特别要改善文献检索,降低文献的选择偏倚,采用Cochrane推荐的标准对纳入原始文献进行质量评价。

Objective： To evaluate the methodological qualities of the systematic review /Meta-analysis（ SR/MA） of Xingnaojing in treating stroke. Method： Chinese biomedical literatures and journals were searched through China National Knowledge Infrastructure,VIP,Wanfang and Cochrane databases. The systematic review /Meta-Analysis of Xingnaojing in treating stroke was included. The search time was ended in January 2015. The Oxman-Guyatt Overview Assessment Questionnaire（ OQAQ） Scale was used to evaluate the methodological and reporting quality of the included SR / MA literatures. Result： A total of 13 SR / MA literatures were included. The included SR / MA had the following shortcomings： incomplete literature search, high selection bias, poor methodological quality of the original articles and low accuracy. The original articles in SR / MA had the following shortcomings： unclear randomizatioon methods,unclear concealment,no blinding,loss to follow-up or intent-totreat（ ITT）,uncertain co-intervention or contamination. Conclusion： The methodological qualities of domestic SR / MA of Xingnaojing in treating stroke were poor. It was necessary to improve the methodological qualities of SR /MA and standardize the experiment design,especially to improve the literature search and reduce the selection bias. The criteria recommended by Cochrane shall be adopted for the quality evaluation of the included original literatures.