3种细胞粘附分子表达与乳腺癌临床病理特征和预后的关系

CORRELATION BETWEEN EXPRESSION OF THREE CELL ADHESION MOLECULES AND CLINICAL PATHOLOGY CHARACTER AND PROGNOSIS IN BREAST CANCER

探讨了唾液酸化的路易斯寡糖 X(sialylLewis X ,SLeX)抗原 ,CD4 4v6和E 上皮钙粘附素 (E cadherin,ED)表达与乳腺癌临床病理生物学行为的关系。应用免疫组化法 ,对 94例乳腺癌组织进行SLeX、CD4 4v6和ED蛋白检测。结果显示 ,SLeX、CD4 4v6阳性表达及ED阴性表达均与乳腺癌的组织学分级、临床分期、淋巴结转移、复发和预后呈正相关。结果表明 ,SLeX、CD4 4v6和ED表达对估计乳腺癌淋巴结转移及患者生存期有重要意义 。

To investigate the relationship of expression of sialyl Lewis X (SLeX) antigen,CD44v6 and E cadherin(ED) with staging,infiltration,node metastasis and prognosis in breast cancer, immunohistochemical method was used to detect their expression in 94 cases of breast cancer.The positive expression of SLeX,CD44v6 and the negative expression of ED were positively correlated with the grading, clinical staging, lymph node metastasis recurrence and prognosis of breast cancer.The results demonstrated that the expression of SLeX, CD44v6 and ED as a clinical valuable marker,has a great significance in assessing node metastasis and prognosis.