已治早期显性梅毒患者血清RPR试验和梅毒螺旋体IgM抗体检查联合随访

Following-up of Early Syphilis with both RPR Test and Tp-IgM-Capture-EL ISA after Treatment

目的探讨RPR试验和梅毒螺旋体(Tp)IgM抗体试验联合检测对于早期梅毒的随访意义。方法病史在1年以内的61例一期梅毒患者和77例二期梅毒患者,于治疗后,每3个月接受RPR试验和梅毒螺旋体IgM抗体捕获ELISA联合检测,为时2年。结果RPR试验不同时间的转阴率分别为6.2%(3个月时)、31.5%(6个月时)、61.5%(9个月时)、83.8%(12个月时)、90.7%(15个月时)、92.3%(18个月时)、94.6%(21个月时)、95.3%(24个月时)。Tp-IgM检查不同时间的转阴率分别为25.4%(3个月时)、56.5%(6个月时)、86.2%(9个月时)、97.1%(12个月时)、100.0%(15个月时)。其中,一期梅毒RPR试验不同时间的转阴率分别为8.2%(3个月时)、31.1%(6个月时)、57.4%(9个月时)、75.4%(12个月时)、83.6%(15个月时)、85.2%(18个月时)、100.0%(21个月时),Tp-IgM检查不同时间的转阴率分别为45.9%(3个月时)、85.2%(6个月时)、98.4%(9个月时)、100.0%(12个月时)。二期梅毒RPR试验不同时间的转阴率分别为2.6%(3个月时)、28.6%(6个月时)、58.4%(9个月时)、81.8%(12个月时)、84.4%(15个月时)、88.3%(18个月时)、90.9%(21个月时)、92.2%(24个月时),Tp-IgM检查不同时间的转阴率分别为9.1%(3个月时)、33.8%(6个月时)、71.4%(9个月时)、94.8%(12个月时)、100.0%(15个月时)。

Objective To explore the significance of RPR te st and Tp -IgM-Capture -ELISA in fol-lowing-up of early syphilis.Methods Sixty-one cases of primary syphilis with less than one-year course and 77cases of secondary syphilis were enr olled into the study.The patients we re followed up by RPR test and Tp -IgM-Capture -ELISAat intervals of three months for two years after treatment .Results By the end of 3,6,9,12,15,18,21and 24months,RPRtest became negative in 6.2%,31.5%,61.5%,83.8%,90.7%,92.3%,94.6%,and95.3%of patients,respectively.By the end of 3,6,9,12and 15months,Tp -IgM-Capture -ELISA became negative in 25.4%,56.5%,86.2%,97.1%and 100.0%of patients,respectiv ely.In primary syphilis the RPR test became nonreactive in 8.2%(3months after treatment ),31.1%(6months),57.4%(9months),75.4%(12months),83.6%(15months),85.2%(18months),and 100.0%(21months)of patients,and Tp -IgM-Cap-ture -ELISA in 45.9%(3months),85.2%(6months),98.4%(9months),100.0%(12months)of patients.In secondary syphilis RPRtest became n onreactive in 2.6%(3months after treatment ),28.6%(6months),58.4%(9months),81.8%(12months),84.4%(15months),88.3%(18months),90.9%(21months)and 92.2%(24months)of patients,and Tp -IgM-Capture -ELISAin 9.1%(3months),33.8%(6months),71.4%(9months),94.8%(12months)and 100.0%(15months)of patients.Tp -IgM-Capture -ELISA was found to be negative earlier than that of RPR test in all ca ses.No sero-resistant was shown in T p -IgM-Capture -ELISA.Conclusions Tp -IgM turns to negative in 12months after treatment for nearly all patie nts with early syphilis.Tp -IgM-Cap-ture -ELISA may be served as a useful t ool to follow up early syphilis patie nts after treatment.[